Tarsal-carpal coalition syndrome

Tarsal-carpal coalition syndrome is an autosomal dominant disorder caused by mutations of the NOG gene. It is characterized by fusion of the carpals, tarsals, and phalanges.

Systematic

Inborn skeletal malformations
	Al-Gazali-Bakalinova syndrome
	Brachydactyly
	Branchio-oculo-facial syndrome
	Congenital contractural arachnodactyly
	Ehlers-Danlos syndrome due to tenascin-X deficiency
	Hydrolethalus 2
	Lacrimoauriculodentodigital syndrome
	Loeys-Dietz syndrome
	Multiple synostoses syndrome
	Multiple synostoses syndrome 3
	Orofacial cleft 11
	Orofaciodigital syndrome
	Periodontal Ehlers-Danlos syndrome
	Proximal symphalangism
	Renal tubular acidosis with arthrogryposis
	Simpson-Golabi-Behmel syndrome
	Stapes ankylosis with broad thumbs and toes
	Syndactyly type 5
	Synpolydactyly type 1
	Tarsal-carpal coalition syndrome
		NOG
	Tatton-Brown-Rahman syndrome
	Townes-Brocks syndrome
	Trigonocephaly 2
	Van Maldergem syndrome 2

References:

1.	Drawbert JP et al. (1985) Tarsal and carpal coalition and symphalangism of the Fuhrmann type. Report of a family.

2.	Dixon ME et al. () Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism.

3.	Gregersen HN et al. (1977) Congenital malformation of the feet with low body height. A new syndrome, caused by an autosomal dominant gene.

4.	OMIM.ORG article Omim 186570

5.	Orphanet article Orphanet ID 1412

Update: June 23, 2025

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