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Susceptibility to glioma

A glioma is a tumor of the central nervous system that starts from glia cells. Susceptibility may be associated with variants in the IDH1 gene.

Systematic

Hereditary brain tumors
Susceptibility to glioma
IDH1
Tuberous sclerosis complex

References:

1.

Piccirillo SG et al. (2006) Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells.

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2.

Singh D et al. (2012) Transforming fusions of FGFR and TACC genes in human glioblastoma.

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3.

Jones DT et al. (2013) Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.

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4.

Parsons DW et al. (2008) An integrated genomic analysis of human glioblastoma multiforme.

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5.

Yan H et al. (2009) IDH1 and IDH2 mutations in gliomas.

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6.

Dubbink HJ et al. (2009) IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide.

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7.

Bralten LB et al. (2011) IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo.

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8.

Flavahan WA et al. (2016) Insulator dysfunction and oncogene activation in IDH mutant gliomas.

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9.

Bredel M et al. (2011) NFKBIA deletion in glioblastomas.

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10.

None (2008) Comprehensive genomic characterization defines human glioblastoma genes and core pathways.

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11.

Thuwe I et al. (1979) Familial brain tumour.

external link
12.

de Tribolet N et al. (1979) Familial gliomas.

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13.

von Motz IP et al. (1977) Astrocytoma in three sisters.

external link
14.

Clarenbach P et al. (1979) Simultaneous clinical manifestation of subependymoma of the fourth ventricle in identical twins. Case report.

external link
15.

Ransom DT et al. (1992) Cytogenetic and loss of heterozygosity studies in ependymomas, pilocytic astrocytomas, and oligodendrogliomas.

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16.

von Deimling A et al. (1992) Evidence for a tumor suppressor gene on chromosome 19q associated with human astrocytomas, oligodendrogliomas, and mixed gliomas.

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17.

Wong AJ et al. (1992) Structural alterations of the epidermal growth factor receptor gene in human gliomas.

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18.

Olopade OI et al. (1992) Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas.

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19.

Sainati L et al. (1992) Cytogenetic t(11;17)(q13;q21) in a pediatric ependymoma. Is 11q13 a recurring breakpoint in ependymomas?

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20.

Griffin CA et al. (1992) Chromosome abnormalities in low-grade central nervous system tumors.

external link
21.

Bigner SH et al. (1990) Cytogenetics and molecular genetics of malignant gliomas and medulloblastoma.

external link
22.

Duhaime AC et al. (1989) Simultaneous presentation of glioblastoma multiforme in siblings two and five years old: case report.

external link
23.

Fujimoto M et al. (1989) Loss of heterozygosity on chromosome 10 in human glioblastoma multiforme.

external link
24.

Geraghty AV et al. (1989) Prenatal diagnosis of fetal glioblastoma multiforme.

external link
25.

el-Azouzi M et al. (1989) Loss of distinct regions on the short arm of chromosome 17 associated with tumorigenesis of human astrocytomas.

external link
26.

Chemke J et al. (1985) Familial glioblastoma multiforme without neurofibromatosis.

external link
27.

Heuch I et al. (1986) Glioblastoma multiforme in three family members, including a case of true multicentricity.

external link
28.

Honan WP et al. (1987) Familial subependymomas.

external link
29.

Bigner SH et al. (1988) Specific chromosomal abnormalities in malignant human gliomas.

external link
30.

Munoz DG et al. (1988) Cerebral malignant tumors with ependymal and choroidal differentiation in two siblings.

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31.

Vieregge P et al. (1987) Familial glioma: occurrence within the "familial cancer syndrome" and systemic malformations.

external link
32.

Leblanc R et al. (1986) Familial mixed oligodendrocytic-astrocytic gliomas.

external link
33.

Henn W et al. (1986) Polysomy of chromosome 7 is correlated with overexpression of the erbB oncogene in human glioblastoma cell lines.

external link
34.

Isamat F et al. (1974) Genetic implications of familial brain tumors.

external link
35.

Armstrong RM et al. (1969) Familial gliomas.

external link
36.

None (1971) Deaths from childhood leukemia and solid tumors among twins and other sibs in the United States, 1960-67.

external link
37.

Downward J et al. () Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences.

external link
38.

Schianchi P et al. (1980) Familial brain tumors: rhombencephalon-astrocytoma grade I in father and son.

external link
39.

Chen P et al. (1995) Constitutional p53 mutations associated with brain tumors in young adults.

external link
40.

Fults D et al. (1993) Deletion mapping of the long arm of chromosome 10 in glioblastoma multiforme.

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41.

Ryken TC et al. (1994) Familial occurrence of subependymoma. Report of two cases.

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42.

Kyritsis AP et al. (1994) Germline p53 gene mutations in subsets of glioma patients.

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43.

Karlbom AE et al. (1993) Loss of heterozygosity in malignant gliomas involves at least three distinct regions on chromosome 10.

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44.

Bögler O et al. (1995) The p53 gene and its role in human brain tumors.

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45.

von Deimling A et al. (1995) Molecular pathways in the formation of gliomas.

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46.

Kimmelman AC et al. (1996) Loss of heterozygosity of chromosome 10p in human gliomas.

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47.

Chattopadhyay P et al. (1997) Loss of heterozygosity of a locus on 17p13.3, independent of p53, is associated with higher grades of astrocytic tumours.

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48.

Mollenhauer J et al. (1997) DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumours.

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49.

Chernova OB et al. (1998) A novel gene, LGI1, from 10q24 is rearranged and downregulated in malignant brain tumors.

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50.

Simons A et al. (1999) Isolation and characterization of glioblastoma-associated homozygously deleted DNA fragments from chromosomal region 9p21 suggests involvement of multiple tumour suppressor genes.

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51.

Smith JS et al. (2000) A transcript map of the chromosome 19q-arm glioma tumor suppressor region.

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52.

Frederick L et al. (2000) Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas.

external link
53.

Ueki K et al. (1997) ANOVA, a putative astrocytic RNA-binding protein gene that maps to chromosome 19q13.3.

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54.

Tachibana I et al. (2000) Investigation of germline PTEN, p53, p16(INK4A)/p14(ARF), and CDK4 alterations in familial glioma.

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55.

Holland EC et al. (2000) Combined activation of Ras and Akt in neural progenitors induces glioblastoma formation in mice.

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56.

Reilly KM et al. (2000) Nf1;Trp53 mutant mice develop glioblastoma with evidence of strain-specific effects.

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57.

Esteller M et al. (2000) Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.

external link
58.

Malmer B et al. (2001) Genetic epidemiology of glioma.

external link
59.

de Andrade M et al. (2001) Segregation analysis of cancer in families of glioma patients.

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60.

Nishimoto A et al. (2001) Functional evidence for a telomerase repressor gene on human chromosome 10p15.1.

external link
61.

Marie Y et al. (2001) OLIG2 as a specific marker of oligodendroglial tumour cells.

external link
62.

Hoang-Xuan K et al. (2001) Molecular heterogeneity of oligodendrogliomas suggests alternative pathways in tumor progression.

external link
63.

Jin W et al. (2000) p53 mutation, EGFR gene amplification and loss of heterozygosity on chromosome 10, 17 p in human gliomas.

external link
64.

Pollack IF et al. (2002) Expression of p53 and prognosis in children with malignant gliomas.

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65.

Gutmann DH et al. (2002) Mouse glioma gene expression profiling identifies novel human glioma-associated genes.

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66.

Cartron PF et al. (2002) The expression of a new variant of the pro-apoptotic molecule Bax, Baxpsi, is correlated with an increased survival of glioblastoma multiforme patients.

external link
67.

Staal FJ et al. (2002) A novel germline mutation of PTEN associated with brain tumours of multiple lineages.

external link
68.

Hu J et al. (2002) High-resolution genome-wide allelotype analysis identifies loss of chromosome 14q as a recurrent genetic alteration in astrocytic tumours.

external link
69.

Leuraud P et al. (2003) Telomerase reactivation in malignant gliomas and loss of heterozygosity on 10p15.1.

external link
70.

KJELLIN K et al. (1960) The occurrence of brain tumors in several members of a family.

external link
71.

PARKINSON D et al. (1962) Oligodendrogliomas. Simultaneous appearance in frontal lobes of siblings.

external link
72.

Yokota T et al. (2003) A family with spinal anaplastic ependymoma: evidence of loss of chromosome 22q in tumor.

external link
73.

Hegi ME et al. (2004) Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide.

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74.

Aldape KD et al. (2004) Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance.

external link
75.

Reilly KM et al. (2004) Susceptibility to astrocytoma in mice mutant for Nf1 and Trp53 is linked to chromosome 11 and subject to epigenetic effects.

external link
76.

Stupp R et al. (2005) Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

external link
77.

Hegi ME et al. (2005) MGMT gene silencing and benefit from temozolomide in glioblastoma.

external link
78.

Liang Y et al. (2005) Gene expression profiling reveals molecularly and clinically distinct subtypes of glioblastoma multiforme.

external link
79.

Mellinghoff IK et al. (2005) Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.

external link
80.

Bao S et al. (2006) Glioma stem cells promote radioresistance by preferential activation of the DNA damage response.

external link
81.

Pfister S et al. (2008) BRAF gene duplication constitutes a mechanism of MAPK pathway activation in low-grade astrocytomas.

external link
82.

Savaskan NE et al. (2008) Small interfering RNA-mediated xCT silencing in gliomas inhibits neurodegeneration and alleviates brain edema.

external link
83.

Blumenthal DT et al. (2008) Familiality in brain tumors.

external link
84.

Zheng H et al. (2008) p53 and Pten control neural and glioma stem/progenitor cell renewal and differentiation.

external link
85.

El Hallani S et al. (2009) TP53 codon 72 polymorphism is associated with age at onset of glioblastoma.

external link
86.

De Carli E et al. (2009) IDH1 and IDH2 mutations in gliomas.

external link
87.

Yu J et al. (2009) Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.

external link
88.

Carro MS et al. (2010) The transcriptional network for mesenchymal transformation of brain tumours.

external link
89.

Kyritsis AP et al. (2010) Inherited predisposition to glioma.

external link
90.

Labussière M et al. (2010) All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2.

external link
91.

Sheng Z et al. (2010) A genome-wide RNA interference screen reveals an essential CREB3L2-ATF5-MCL1 survival pathway in malignant glioma with therapeutic implications.

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92.

Johnson RA et al. (2010) Cross-species genomics matches driver mutations and cell compartments to model ependymoma.

external link
93.

Wang R et al. (2010) Glioblastoma stem-like cells give rise to tumour endothelium.

external link
94.

Ricci-Vitiani L et al. (2010) Tumour vascularization via endothelial differentiation of glioblastoma stem-like cells.

external link
95.

Bettegowda C et al. (2011) Mutations in CIC and FUBP1 contribute to human oligodendroglioma.

external link
96.

Schwartzentruber J et al. (2012) Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma.

external link
97.

Wu G et al. (2012) Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.

external link
98.

Muller FL et al. (2012) Passenger deletions generate therapeutic vulnerabilities in cancer.

external link
99.

Lewis PW et al. (2013) Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

external link
100.

Frattini V et al. (2013) The integrated landscape of driver genomic alterations in glioblastoma.

external link
101.

Parker M et al. (2014) C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.

external link
102.

Mack SC et al. (2014) Epigenomic alterations define lethal CIMP-positive ependymomas of infancy.

external link
103.

Funato K et al. (2014) Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation.

external link
104.

Kim D et al. (2015) SHMT2 drives glioma cell survival in ischaemia but imposes a dependence on glycine clearance.

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105.

et al. (2015) Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.

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106.

Eckel-Passow JE et al. (2015) Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors.

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107.

Jahani-Asl A et al. (2016) Control of glioblastoma tumorigenesis by feed-forward cytokine signaling.

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108.

OMIM.ORG article

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