Preeclampsia 1 is a disease of pregnancy that occurs after the 20th week of gestation. It is characterized by hypertension and proteinuria and it can develop into a life threatening eclampsia. Inheritance is autosomal dominant but the gene yet unknown. Locus is 2p13 as identified in an Icelandic study.
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Uzan J et al. (2011) Pre-eclampsia: pathophysiology, diagnosis, and management. |
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Laasanen J et al. (2002) Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia. |
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Maynard SE et al. (2003) Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. |
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None (2003) The genetics of pre-eclampsia: a feto-placental or maternal problem? |
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Faisel F et al. (2004) Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation. |
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Levine RJ et al. (2004) Circulating angiogenic factors and the risk of preeclampsia. |
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Cnattingius S et al. (2004) Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study. |
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None (2005) Disentangling fetal and maternal susceptibility for pre-eclampsia: a British multicenter candidate-gene study. |
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Uz E et al. (2007) Extremely skewed X-chromosome inactivation is increased in pre-eclampsia. |
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Kanasaki K et al. (2008) Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia. |
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Berends AL et al. (2008) Familial aggregation of preeclampsia and intrauterine growth restriction in a genetically isolated population in The Netherlands. |
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Zhou CC et al. (2008) Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice. |
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Payne B et al. (2011) Assessment, surveillance and prognosis in pre-eclampsia. |
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Wallukat G et al. (1999) Patients with preeclampsia develop agonistic autoantibodies against the angiotensin AT1 receptor. |
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van Dijk M et al. (2012) HELLP babies link a novel lincRNA to the trophoblast cell cycle. |
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Oudejans CB et al. (2015) Susceptibility allele-specific loss of miR-1324-mediated silencing of the INO80B chromatin-assembly complex gene in pre-eclampsia. |
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Cooper DW et al. (1979) Genetic control of severe pre-eclampsia. |
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Hayward C et al. (1992) An exclusion map for pre-eclampsia: assuming autosomal recessive inheritance. |
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Liston WA et al. (1991) Is genetic susceptibility to pre-eclampsia conferred by homozygosity for the same single recessive gene in mother and fetus? |
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Wilton AN et al. (1990) Absence of close linkage between maternal genes for susceptibility to pre-eclampsia/eclampsia and HLA DR beta. |
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Arngrimsson R et al. (1990) Genetic and familial predisposition to eclampsia and pre-eclampsia in a defined population. |
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Kilpatrick DC et al. (1989) Association between susceptibility to pre-eclampsia within families and HLA DR4. |
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None (1988) Genetics of pre-eclampsia. |
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Davey DA et al. (1988) The classification and definition of the hypertensive disorders of pregnancy. |
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Cooper DW et al. (1988) Genetic control of susceptibility to eclampsia and miscarriage. |
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Chesley LC et al. (1986) Genetics of hypertension in pregnancy: possible single gene control of pre-eclampsia and eclampsia in the descendants of eclamptic women. |
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Lachmeijer AM et al. (2001) A genome-wide scan for preeclampsia in the Netherlands. |
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Hillermann R et al. (2005) The Glu298Asp variant of the endothelial nitric oxide synthase gene is associated with an increased risk for abruptio placentae in pre-eclampsia. |
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Hiby SE et al. (2004) Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success. |
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Chesley LC et al. (1968) The familial factor in toxemia of pregnancy. |
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None (1980) Genetic control of pre-eclampsia. |
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Fisher KA et al. (1981) Hypertension in pregnancy: clinical-pathological correlations and remote prognosis. |
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Van Meter TD et al. (1993) Concerns about the genetics of pre-eclampsia. |
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Brenner B et al. (1996) HELLP syndrome associated with factor V R506Q mutation. |
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Harrison GA et al. (1997) A genomewide linkage study of preeclampsia/eclampsia reveals evidence for a candidate region on 4q. |
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Sohda S et al. (1997) Methylenetetrahydrofolate reductase polymorphism and pre-eclampsia. |
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Arngrímsson R et al. (1997) Evidence for a familial pregnancy-induced hypertension locus in the eNOS-gene region. |
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Lindqvist PG et al. (1998) Factor V Q506 mutation (activated protein C resistance) associated with reduced intrapartum blood loss--a possible evolutionary selection mechanism. |
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Kupferminc MJ et al. (1999) Increased frequency of genetic thrombophilia in women with complications of pregnancy. |
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Thornton JG et al. (1999) Twin mothers, pregnancy hypertension and pre-eclampsia. |
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Arngrímsson R et al. (1999) A genome-wide scan reveals a maternal susceptibility locus for pre-eclampsia on chromosome 2p13. |
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Zusterzeel PL et al. (1999) Glutathione S-transferase isoenzymes in decidua and placenta of preeclamptic pregnancies. |
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Page NM et al. (2000) Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. |
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Brown MA et al. (2000) The detection, investigation and management of hypertension in pregnancy: full consensus statement. |
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Moses EK et al. (2000) A genome scan in families from Australia and New Zealand confirms the presence of a maternal susceptibility locus for pre-eclampsia, on chromosome 2. |
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Roberts JM et al. (2001) Pathogenesis and genetics of pre-eclampsia. |
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Esplin MS et al. (2001) Paternal and maternal components of the predisposition to preeclampsia. |
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Zusterzeel PL et al. (2001) A polymorphism in the gene for microsomal epoxide hydrolase is associated with pre-eclampsia. |
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Zusterzeel PL et al. (2002) Paternal contribution to the risk for pre-eclampsia. |
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OMIM.ORG article Omim 189800 |