Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Graft-versus-host disease protection

Protection against graft-versus-host reaction can be conditioned by genetic variants in the IL10 gene which encodes interleukin 10.

Systematic

Hereditary immunological disorders
Atopy
Autoimmune disease
Autoinflammatory disease
Chediak-Higashi syndrome
Graft-versus-host disease protection
IL10
Griscelli syndrome type 2
Hereditary complement disorders
Immunoglobulin disorders
Interferonopathy
Primary immunodeficiency
Susceptibility to allergic rhinitis
Susceptibility to asthma

References:

1.

Eskdale J et. al. (1997) Mapping of the human IL10 gene and further characterization of the 5' flanking sequence.

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2.

Cooke KR et. al. (2003) A protective gene for graft-versus-host disease.

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3.

Lin MT et. al. (2003) Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation.

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4.

Petersdorf EW et. al. (2006) Genetics of risk factors for graft-versus-host disease.

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Update: Aug. 14, 2020
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