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Susceptibility to type 1 diabetes 02

Autoimmune diabetes 02 is a diabetes mellitus type 1 that are pathogentically linked to genetic variants in the INS gene.

Systematic

Susceptibility to type 1 diabetes
Susceptibility to type 1 diabetes 01
Susceptibility to type 1 diabetes 02
INS
Susceptibility to type 1 diabetes 03
Susceptibility to type 1 diabetes 04
Susceptibility to type 1 diabetes 05
Susceptibility to type 1 diabetes 06
Susceptibility to type 1 diabetes 07
Susceptibility to type 1 diabetes 08
Susceptibility to type 1 diabetes 09
Susceptibility to type 1 diabetes 10
Susceptibility to type 1 diabetes 11
Susceptibility to type 1 diabetes 12
Susceptibility to type 1 diabetes 13
Susceptibility to type 1 diabetes 15
Susceptibility to type 1 diabetes 17
Susceptibility to type 1 diabetes 18
Susceptibility to type 1 diabetes 19
Susceptibility to type 1 diabetes 20
Susceptibility to type 1 diabetes 21
Susceptibility to type 1 diabetes 22
Susceptibility to type 1 diabetes 23
Susceptibility to type 1 diabetes 24

References:

1.

Bell GI et al. (1981) Polymorphic DNA region adjacent to the 5' end of the human insulin gene.

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2.

Lew A et al. (2000) Unusual DNA structure of the diabetes susceptibility locus IDDM2 and its effect on transcription by the insulin promoter factor Pur-1/MAZ.

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3.

Ong KK et al. (1999) The insulin gene VNTR, type 2 diabetes and birth weight.

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4.

Bennett ST et al. (1997) Insulin VNTR allele-specific effect in type 1 diabetes depends on identity of untransmitted paternal allele. The IMDIAB Group.

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5.

Kawaguchi Y et al. (1997) Insulin gene region contributes to genetic susceptibility to, but may not to low incidence of, insulin-dependent diabetes mellitus in Japanese.

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6.

Pugliese A et al. (1997) The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes.

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7.

Vafiadis P et al. (1997) Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus.

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8.

Bennett ST et al. (1996) Human type 1 diabetes and the insulin gene: principles of mapping polygenes.

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9.

Bennett ST et al. (1996) IDDM2-VNTR-encoded susceptibility to type 1 diabetes: dominant protection and parental transmission of alleles of the insulin gene-linked minisatellite locus.

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10.

Vafiadis P et al. (1996) Imprinted and genotype-specific expression of genes at the IDDM2 locus in pancreas and leucocytes.

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11.

Davies JL et al. (1994) A genome-wide search for human type 1 diabetes susceptibility genes.

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12.

Kennedy GC et al. (1995) The minisatellite in the diabetes susceptibility locus IDDM2 regulates insulin transcription.

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13.

Bennett ST et al. (1995) Susceptibility to human type 1 diabetes at IDDM2 is determined by tandem repeat variation at the insulin gene minisatellite locus.

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14.

Cordell HJ et al. (1995) Two-locus maximum lod score analysis of a multifactorial trait: joint consideration of IDDM2 and IDDM4 with IDDM1 in type 1 diabetes.

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15.

Bell GI et al. (1984) A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus.

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16.

Neel JV et al. (1998) Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": the "thrifty genotype" hypothesis enters the 21st century.

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17.

Thomson G et al. (1989) HLA and insulin gene associations with IDDM.

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18.

None (1990) Linkage strategies for genetically complex traits. I. Multilocus models.

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19.

Hales CN et al. (1991) Fetal and infant growth and impaired glucose tolerance at age 64.

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20.

Julier C et al. (1991) Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility.

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21.

Bain SC et al. (1992) Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals.

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22.

Barrett JC et al. (2009) Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.

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23.

Cooper JD et al. (2008) Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

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24.

None (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls.

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25.

Spielman RS et al. (1993) Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

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26.

Molven A et al. (2008) Mutations in the insulin gene can cause MODY and autoantibody-negative type 1 diabetes.

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27.

None (1998) Weighing in on diabetes risk.

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28.

Dunger DB et al. (1998) Association of the INS VNTR with size at birth. ALSPAC Study Team. Avon Longitudinal Study of Pregnancy and Childhood.

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29.

None (1962) Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress"?

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Update: Aug. 14, 2020
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