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Multiple endocrine neoplasia 1

Multiple endocrine neoplasia 1 is an autosomal dominant disorder caused by mutations of the MEN1 gene.

Systematic

Hereditary endocrinological diseases
Autoimmune polyendokrinopathy
Disorder of the thyroid hormon system
Disorders of sex development
Disorders of the growth control system
Disorders of the parathyroid hormone system
Genetic adrenal disease
Genetic disorders of pituitary gland
Hereditary diabetes insipidus
Hereditary dsorders of the pituitary gland
Kidney disease appearing as endocrinological disorders
Multiple endocrine neoplasia 1
MEN1

References:

1.

Courseaux A et al. (1996) Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. The European Consortium on Men1, (GENEM 1; Groupe d'Etude des Néoplasies Endocriniennes Multiples de type 1).

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2.

Rochelle JM et al. (1992) A linkage map of mouse chromosome 19: definition of comparative mapping relationships with human chromosomes 10 and 11 including the MEN1 locus.

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3.

Simonds WF et al. (2004) Familial isolated hyperparathyroidism is rarely caused by germline mutation in HRPT2, the gene for the hyperparathyroidism-jaw tumor syndrome.

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4.

Bear JC et al. (1985) Variant multiple endocrine neoplasia I (MEN IBurin): further studies and non-linkage to HLA.

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5.

Farid NR et al. (1980) Prolactinomas in familial multiple endocrine neoplasia syndrome type I. Relationship to HLA and carcinoid tumors.

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6.

Chandrasekharappa SC et al. (1997) Positional cloning of the gene for multiple endocrine neoplasia-type 1.

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7.

Agarwal SK et al. (1997) Germline mutations of the MEN1 gene in familial multiple endocrine neoplasia type 1 and related states.

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8.

Lemmens I et al. (1997) Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.

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9.

Darling TN et al. (1997) Multiple facial angiofibromas and collagenomas in patients with multiple endocrine neoplasia type 1.

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10.

Heppner C et al. (1997) Somatic mutation of the MEN1 gene in parathyroid tumours.

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11.

Bassett JH et al. (1998) Characterization of mutations in patients with multiple endocrine neoplasia type 1.

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12.

Guru SC et al. (1998) Menin, the product of the MEN1 gene, is a nuclear protein.

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13.

Vortmeyer AO et al. (1998) Multiple endocrine neoplasia 1 gene alterations in MEN1-associated and sporadic lipomas.

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14.

Prezant TR et al. (1998) Molecular characterization of the men1 tumor suppressor gene in sporadic pituitary tumors.

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15.

Olufemi SE et al. (1998) Common ancestral mutation in the MEN1 gene is likely responsible for the prolactinoma variant of MEN1 (MEN1Burin) in four kindreds from Newfoundland.

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16.

Giraud S et al. (1998) Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders.

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17.

Teh BT et al. (1998) Mutation analysis of the MEN1 gene in multiple endocrine neoplasia type 1, familial acromegaly and familial isolated hyperparathyroidism.

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18.

Farnebo F et al. (1998) Alterations of the MEN1 gene in sporadic parathyroid tumors.

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19.

Carling T et al. (1998) Parathyroid MEN1 gene mutations in relation to clinical characteristics of nonfamilial primary hyperparathyroidism.

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20.

Fujimori M et al. (1998) Novel V184E MEN1 germline mutation in a Japanese kindred with familial hyperparathyroidism.

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21.

Heppner C et al. (1999) MEN1 gene analysis in sporadic adrenocortical neoplasms.

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22.

Kjellman M et al. (1999) Genotyping of adrenocortical tumors: very frequent deletions of the MEN1 locus in 11q13 and of a 1-centimorgan region in 2p16.

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23.

Gisselsson D et al. (1999) Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics.

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24.

Cebrián A et al. (1999) Genetic and clinical analysis in 10 Spanish patients with multiple endocrine neoplasia type 1.

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25.

Tahara H et al. (2000) Rare somatic inactivation of the multiple endocrine neoplasia type 1 gene in secondary hyperparathyroidism of uremia.

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26.

Crabtree JS et al. (2001) A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.

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27.

Pannett AA et al. (2001) Somatic mutations in MEN type 1 tumors, consistent with the Knudson "two-hit" hypothesis.

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28.

Guo SS et al. (2001) Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1.

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29.

Sato K et al. (2001) Somatic mutations of the MEN1 gene and microsatellite instability in a case of tertiary hyperparathyroidism occurring during high phosphate therapy for acquired, hypophosphatemic osteomalacia.

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30.

Turner JJ et al. (2002) Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1.

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31.

Wautot V et al. (2002) Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein.

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32.

Okamoto H et al. (2002) A novel six-nucleotide insertion in exon 4 of the MEN1 gene, 878insCTGCAG, in three patients with familial insulinoma and primary hyperparathyroidism.

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33.

Park JH et al. (2003) Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders.

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34.

Ebeling T et al. (2004) Effect of multiple endocrine neoplasia type 1 (MEN1) gene mutations on premature mortality in familial MEN1 syndrome with founder mutations.

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35.

Busygina V et al. (2004) Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1.

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36.

Farnebo F et al. (1999) Alternative genetic pathways in parathyroid tumorigenesis.

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37.

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38.

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39.

Mallette LE et al. (1974) Parathyroid carcinoma in familial hyperparathyroidism.

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40.

Tanaka C et al. (1998) Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese.

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41.

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42.

McCarthy DM et al. (1977) H2-Histamine receptor blocking agents in the Zollinger-Ellison syndrome. Experience in seven cases and implications for long-term therapy.

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43.

Lamers CB et al. (1978) Prevalence of endocrine abnormalities in patients with the Zollinger-Ellison syndrome and in their families.

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44.

Lamers CB et al. (1979) Clinical significance of hyperparathyroidism in familial multiple endocrine adenomatosis type I (MEA I).

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45.

Prosser PR et al. (1979) Prolactin-secreting pituitary adenomas in multiple endocrine adenomatosis, type I.

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46.

Stadil F et al. (1976) Treatment of Zollinger-Ellison syndrome with streptozotocin.

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47.

Straus E et al. (1977) Canine Zollinger-Ellison syndrome.

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48.

Tateishi R et al. (1978) Coexistence of bilateral pheochromocytoma and pancreatic islet cell tumor: report of a case and review of the literature.

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49.

Regan PT et al. (1978) A reappraisal of clinical, roentgenographic, and endoscopic features of the Zollinger-Ellison syndrome.

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50.

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51.

Cocco AE et al. (1975) Zollinger-Ellison syndrome associated with ovarian mucinous cystadenocarcinoma.

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52.

Larsson C et al. (1992) Predictive testing for multiple endocrine neoplasia type 1 using DNA polymorphisms.

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53.

Sawicki MP et al. (1992) Loss of heterozygosity on chromosome 11 in sporadic gastrinomas.

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54.

Skogseid B et al. (1992) Clinical and genetic features of adrenocortical lesions in multiple endocrine neoplasia type 1.

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55.

Richard CW et al. (1991) A radiation hybrid map of the proximal long arm of human chromosome 11 containing the multiple endocrine neoplasia type 1 (MEN-1) and bcl-1 disease loci.

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56.

Fujimori M et al. (1992) Fine-scale mapping of the gene responsible for multiple endocrine neoplasia type 1 (MEN 1).

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57.

Byström C et al. (1990) Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors.

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58.

Nakamura Y et al. (1989) Localization of the genetic defect in multiple endocrine neoplasia type 1 within a small region of chromosome 11.

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59.

Bale SJ et al. (1989) Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11.

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60.

Friedman E et al. (1989) Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1.

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61.

Thakker RV et al. (1989) Association of parathyroid tumors in multiple endocrine neoplasia type 1 with loss of alleles on chromosome 11.

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62.

Brandi ML et al. (1986) Parathyroid mitogenic activity in plasma from patients with familial multiple endocrine neoplasia type 1.

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63.

None (1986) Multiple endocrine neoplasia: search for the oncogenic trigger.

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64.

Maton PN et al. (1986) Cushing's syndrome in patients with the Zollinger-Ellison syndrome.

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65.

Bahn RS et al. (1986) Nonidentical expressions of multiple endocrine neoplasia, type I, in identical twins.

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66.

Larsson C et al. (1988) Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma.

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67.

Chedid A et al. (1988) Hereditary pituitary prolactinomas: a new rat model.

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68.

Wolfe MM et al. (1987) Zollinger-Ellison syndrome. Current concepts in diagnosis and management.

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69.

Guida PM et al. (1966) Zollinger-Ellison syndrome with interesting variations. Report of twelve cases including one of carcinoid of the duodenum.

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70.

Jones BS et al. (1970) A case of the Zollinger-Ellison syndrome associated with hyperplasia of salivary and Brunner's glands.

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71.

Friesen SR et al. (1972) Genetic aspects of the Z-E syndrome: prospective studies in two kindred; antral gastrin cell hyperplasia.

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72.

Johnson GJ et al. (1967) Clinical and genetic investigation of a large kindred with multiple endocrine adenomatosis.

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73.

Lulu DJ et al. (1968) Familial endocrine adenomatosis with associated Zollinger-Ellison syndrome. Wermer's syndrome.

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74.

Way L et al. (1968) Zollinger-Ellison syndrome. An analysis of twenty-five cases.

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75.

Vance JE et al. (1969) Nesidioblastosis in familial endocrine adenomatosis.

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76.

Vance JE et al. (1972) Familial nesidioblastosis as the predominant manifestation of multiple endocrine adenomatosis.

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77.

Snyder N et al. (1972) Five families with multiple endocrine adenomatosis.

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78.

Ellison EH et al. (1967) The Zollinger-Ellison syndrome updated.

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79.

Buchta RM et al. (1971) Zollinger-Ellison syndrome in a nine-year-old child: a case report and review of the entity in childhood.

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80.

Betts JB et al. (1980) Hyperparathyroidism: a prerequisite for Zollinger-Ellison syndrome in multiple endocrine adenomatosis Type 1--report of a further family and a review of th literature.

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81.

Reimer D et al. (1981) A kindred with 5 cases of multiple endocrine adenomatosis type I.

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82.

Stacpoole PW et al. (1981) A familial glucagonoma syndrome: genetic, clinical and biochemical features.

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83.

Mee AS et al. (1983) Changing concepts in the presentation, diagnosis and management of the Zollinger-Ellison syndrome.

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84.

None (1984) Genetic aspects of multiple endocrine neoplasia.

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85.

Hershon KS et al. (1983) Prolactinomas as part of the multiple endocrine neoplastic syndrome type 1.

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86.

None (1982) Zollinger-Ellison syndrome.

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87.

Long TT et al. (1980) Conservative management of the Zollinger-Ellison syndrome. Ectopic gastrin production by an ovarian cystadenoma.

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88.

Petty EM et al. (1994) Mapping the gene for hereditary hyperparathyroidism and prolactinoma (MEN1Burin) to chromosome 11q: evidence for a founder effect in patients from Newfoundland.

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89.

Gaitan D et al. (1993) Two patients with Cushing's disease in a kindred with multiple endocrine neoplasia type I.

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90.

Guru SC et al. (1997) A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.

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91.

Lemmens I et al. (1997) Construction of a 1.2-Mb sequence-ready contig of chromosome 11q13 encompassing the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.

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92.

None (1998) Multiple endocrine neoplasia--syndromes of the twentieth century.

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93.

Sato M et al. (1998) Identification of five novel germline mutations of the MEN1 gene in Japanese multiple endocrine neoplasia type 1 (MEN1) families.

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94.

Yu F et al. (1999) Prospective study of the clinical course, prognostic factors, causes of death, and survival in patients with long-standing Zollinger-Ellison syndrome.

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95.

Guru SC et al. (1999) Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene.

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96.

Hessman O et al. (2001) Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors.

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97.

Schussheim DH et al. () Multiple endocrine neoplasia type 1: new clinical and basic findings.

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98.

Bordi C et al. (2001) The antral mucosa as a new site for endocrine tumors in multiple endocrine neoplasia type 1 and Zollinger-Ellison syndromes.

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99.

Brandi ML et al. (2001) Guidelines for diagnosis and therapy of MEN type 1 and type 2.

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100.

Vergès B et al. (2002) Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study.

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101.

None (1954) Genetic aspects of adenomatosis of endocrine glands.

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102.

ZOLLINGER RM et al. (1955) Primary peptic ulcerations of the jejunum associated with islet cell tumors of the pancreas.

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103.

WILLIAMS ED et al. (1962) The association of bronchial carcinoid and pluriglandular adenomatosis.

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104.

UNDERWOOD LE et al. (1963) FAMILIAL ENDOCRINE ADENOMATOSIS. A FAMILY WITH HYPERINSULINISM AS THE PREDOMINANT MANIFESTATION.

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105.

BALLARD HS et al. (1964) FAMILIAL MULTIPLE ENDOCRINE ADENOMA-PEPTIC ULCER COMPLEX.

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106.

ELLISON EH et al. (1964) THE ZOLLINGER-ELLISON SYNDROME: RE-APPRAISAL AND EVALUATION OF 260 REGISTERED CASES.

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107.

Hao W et al. (2004) Multiple endocrine neoplasia type 1 variant with frequent prolactinoma and rare gastrinoma.

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108.

Asgharian B et al. (2004) Cutaneous tumors in patients with multiple endocrine neoplasm type 1 (MEN1) and gastrinomas: prospective study of frequency and development of criteria with high sensitivity and specificity for MEN1.

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109.

Scacheri PC et al. (2004) Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1.

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110.

Perren A et al. (2007) Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas.

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111.

Lemos MC et al. (2008) Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene.

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