Multiple endocrine neoplasia 1

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Guru SC et al. (1998) Menin, the product of the MEN1 gene, is a nuclear protein.

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Gisselsson D et al. (1999) Hibernomas are characterized by homozygous deletions in the multiple endocrine neoplasia type I region. Metaphase fluorescence in situ hybridization reveals complex rearrangements not detected by conventional cytogenetics.

Cebrián A et al. (1999) Genetic and clinical analysis in 10 Spanish patients with multiple endocrine neoplasia type 1.

Tahara H et al. (2000) Rare somatic inactivation of the multiple endocrine neoplasia type 1 gene in secondary hyperparathyroidism of uremia.

Crabtree JS et al. (2001) A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.

Pannett AA et al. (2001) Somatic mutations in MEN type 1 tumors, consistent with the Knudson "two-hit" hypothesis.

Guo SS et al. (2001) Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1.

Sato K et al. (2001) Somatic mutations of the MEN1 gene and microsatellite instability in a case of tertiary hyperparathyroidism occurring during high phosphate therapy for acquired, hypophosphatemic osteomalacia.

Turner JJ et al. (2002) Frequent occurrence of an intron 4 mutation in multiple endocrine neoplasia type 1.

Wautot V et al. (2002) Germline mutation profile of MEN1 in multiple endocrine neoplasia type 1: search for correlation between phenotype and the functional domains of the MEN1 protein.

Okamoto H et al. (2002) A novel six-nucleotide insertion in exon 4 of the MEN1 gene, 878insCTGCAG, in three patients with familial insulinoma and primary hyperparathyroidism.

Park JH et al. (2003) Germline mutations of the MEN1 gene in Korean families with multiple endocrine neoplasia type 1 (MEN1) or MEN1-related disorders.

Ebeling T et al. (2004) Effect of multiple endocrine neoplasia type 1 (MEN1) gene mutations on premature mortality in familial MEN1 syndrome with founder mutations.

Busygina V et al. (2004) Hypermutability in a Drosophila model for multiple endocrine neoplasia type 1.

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Tanaka C et al. (1998) Absence of germ-line mutations of the multiple endocrine neoplasia type 1 (MEN1) gene in familial pituitary adenoma in contrast to MEN1 in Japanese.

None (1976) Multiple endocrine adenomatosis syndromes.

McCarthy DM et al. (1977) H2-Histamine receptor blocking agents in the Zollinger-Ellison syndrome. Experience in seven cases and implications for long-term therapy.

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Richard CW et al. (1991) A radiation hybrid map of the proximal long arm of human chromosome 11 containing the multiple endocrine neoplasia type 1 (MEN-1) and bcl-1 disease loci.

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Bale SJ et al. (1989) Linkage analysis of multiple endocrine neoplasia type 1 with INT2 and other markers on chromosome 11.

Friedman E et al. (1989) Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1.

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None (1986) Multiple endocrine neoplasia: search for the oncogenic trigger.

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Bahn RS et al. (1986) Nonidentical expressions of multiple endocrine neoplasia, type I, in identical twins.

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None (1984) Genetic aspects of multiple endocrine neoplasia.

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None (1982) Zollinger-Ellison syndrome.

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Guru SC et al. (1997) A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus.

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None (1998) Multiple endocrine neoplasia--syndromes of the twentieth century.

Sato M et al. (1998) Identification of five novel germline mutations of the MEN1 gene in Japanese multiple endocrine neoplasia type 1 (MEN1) families.

Yu F et al. (1999) Prospective study of the clinical course, prognostic factors, causes of death, and survival in patients with long-standing Zollinger-Ellison syndrome.

Guru SC et al. (1999) Isolation, genomic organization, and expression analysis of Men1, the murine homolog of the MEN1 gene.

Hessman O et al. (2001) Multiple allelic deletions and intratumoral genetic heterogeneity in men1 pancreatic tumors.

Schussheim DH et al. () Multiple endocrine neoplasia type 1: new clinical and basic findings.

Bordi C et al. (2001) The antral mucosa as a new site for endocrine tumors in multiple endocrine neoplasia type 1 and Zollinger-Ellison syndromes.

Brandi ML et al. (2001) Guidelines for diagnosis and therapy of MEN type 1 and type 2.

Vergès B et al. (2002) Pituitary disease in MEN type 1 (MEN1): data from the France-Belgium MEN1 multicenter study.

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Hao W et al. (2004) Multiple endocrine neoplasia type 1 variant with frequent prolactinoma and rare gastrinoma.

Asgharian B et al. (2004) Cutaneous tumors in patients with multiple endocrine neoplasm type 1 (MEN1) and gastrinomas: prospective study of frequency and development of criteria with high sensitivity and specificity for MEN1.

Scacheri PC et al. (2004) Homozygous loss of menin is well tolerated in liver, a tissue not affected in MEN1.

Perren A et al. (2007) Multiple endocrine neoplasia type 1 (MEN1): loss of one MEN1 allele in tumors and monohormonal endocrine cell clusters but not in islet hyperplasia of the pancreas.

Lemos MC et al. (2008) Multiple endocrine neoplasia type 1 (MEN1): analysis of 1336 mutations reported in the first decade following identification of the gene.