Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Mitochondrial ND2 gene

The ensemble of all mitochondrial genes is tested if a mitochondrial disorder has to be diagnosed.


Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:



Walker JE et al. (1992) Sequences of 20 subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Application of a novel strategy for sequencing proteins using the polymerase chain reaction.

external link

Cummins JM et al. (1998) Fate of microinjected spermatid mitochondria in the mouse oocyte and embryo.

external link

Shitara H et al. (1998) Maternal inheritance of mouse mtDNA in interspecific hybrids: segregation of the leaked paternal mtDNA followed by the prevention of subsequent paternal leakage.

external link

Tanaka M et al. (1998) Mitochondrial genotype associated with longevity.

external link

Gyllensten U et al. (1991) Paternal inheritance of mitochondrial DNA in mice.

external link

Pulkes T et al. (2005) Nonsense mutations in mitochondrial DNA associated with myalgia and exercise intolerance.

external link

Yao YG et al. (2002) Mitochondrial DNA 5178A polymorphism and longevity.

external link

Schwartz M et al. (2002) Paternal inheritance of mitochondrial DNA.

external link

Kokaze A et al. (2001) Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population.

external link

Brown MD et al. (2001) Novel mtDNA mutations and oxidative phosphorylation dysfunction in Russian LHON families.

external link

Shitara H et al. (2000) Selective and continuous elimination of mitochondria microinjected into mouse eggs from spermatids, but not from liver cells, occurs throughout embryogenesis.

external link

Ojala D et al. (1981) tRNA punctuation model of RNA processing in human mitochondria.

external link

Montoya J et al. (1981) Distinctive features of the 5'-terminal sequences of the human mitochondrial mRNAs.

external link

Anderson S et al. (1981) Sequence and organization of the human mitochondrial genome.

external link

Attardi G et al. (1982) Identification and mapping of human mitochondrial genes.

external link

Oliver NA et al. (1982) Assignment of two mitochondrially synthesized polypeptides to human mitochondrial DNA and their use in the study of intracellular mitochondrial interaction.

external link

Oliver N et al. (1984) Comparison of mitochondrially synthesized polypeptides of human, mouse, and monkey cell lines by a two-dimensional protease gel system.

external link

Case JT et al. (1981) Maternal inheritance of mitochondrial DNA polymorphisms in cultured human fibroblasts.

external link

Giles RE et al. (1980) Maternal inheritance of human mitochondrial DNA.

external link

Chomyn A et al. () Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase.

external link

Chomyn A et al. (1986) URF6, last unidentified reading frame of human mtDNA, codes for an NADH dehydrogenase subunit.

external link

Wallace DC et al. (1986) Computer prediction of peptide maps: assignment of polypeptides to human and mouse mitochondrial DNA genes by analysis of two-dimensional-proteolytic digest gels.

external link

Johns DR et al. (1991) Alternative, simultaneous complex I mitochondrial DNA mutations in Leber's hereditary optic neuropathy.

external link

Brown MD et al. (1992) Mitochondrial DNA complex I and III mutations associated with Leber's hereditary optic neuropathy.

external link

Hinttala R et al. (2006) Analysis of mitochondrial DNA sequences in patients with isolated or combined oxidative phosphorylation system deficiency.

external link

Arizmendi JM et al. (1992) Complementary DNA sequences of two 14.5 kDa subunits of NADH:ubiquinone oxidoreductase from bovine heart mitochondria. Completion of the primary structure of the complex?

external link

Orphanet article

Orphanet ID 123542 external link

NCBI article

NCBI 4536 external link

OMIM.ORG article

Omim 516001 external link
Update: Aug. 14, 2020
Copyright © 2005-2022 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues | Website Credits