Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The APOF gene encodes apolipoprotein F, a protein formerly known as lipid transfer inhibitor protein (LTIP), is synthesized by the liver and activated in the circulation. It inhibits the CETP and LCAT probably in a way to control the direction of lipid transfer. The activation of apolipoprotein F depends on the composition of LDL particles. While apolipoprotein F deficiency did not significantly alter the lipid profile, overexpression reduces HDL.
| Research | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Lagor WR et al. (2009) Overexpression of apolipoprotein F reduces HDL cholesterol levels in vivo. 
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| 2. |
Olofsson SO et al. (1978) Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma.
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| 3. |
Lagor WR et al. (2012) The effects of apolipoprotein F deficiency on high density lipoprotein cholesterol metabolism in mice.
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| 4. |
Koren E et al. (1982) Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma.
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| 5. |
Day JR et al. (1994) Purification and molecular cloning of human apolipoprotein F.
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| 6. |
Wang X et al. (1999) Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F.
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| 7. |
OMIM.ORG article Omim 107760
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| 8. |
NCBI article NCBI 319
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| 9. |
Wikipedia article Wikipedia EN (APOF)
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