Fibronectin 1
The FN1 gene encodes fibronectin, a glycoprotein present in a soluble dimeric form in plasma, and in a dimeric or multimeric form at the cell surface and in extracellular matrix. Mutation of the gene cause autosomal dominant familial glomerular nephritis with fibronectin deposits type 2.
Genetests:
Related Diseases:
References:
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Kornblihtt AR et al. (1984) Human fibronectin: molecular cloning evidence for two mRNA species differing by an internal segment coding for a structural domain.
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Sekiguchi K et al. (1986) Human liver fibronectin complementary DNAs: identification of two different messenger RNAs possibly encoding the alpha and beta subunits of plasma fibronectin.
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3. |
Zneimer SM et al. (1988) Regional localization of the fibronectin and gamma crystallin genes to mouse chromosome 1 by in situ hybridization.
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4. |
Prowse KR et al. (1986) Assignment of the human fibronectin structural gene to chromosome 2.
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5. |
Gutman A et al. (1987) Identification of a third region of cell-specific alternative splicing in human fibronectin mRNA.
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6. |
Odermatt E et al. (1985) Repeating modular structure of the fibronectin gene: relationship to protein structure and subunit variation.
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7. |
Jhanwar SC et al. (1986) In situ localization of human fibronectin (FN) genes to chromosome regions 2p14--p16, 2q34q36, and 11q12.1--q13.5 in germ line cells, but to chromosome 2 sites only in somatic cells.
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8. |
Zardi L et al. (1979) Fibronectin: a chromatin-associated protein?
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9. |
Eun CK et al. (1980) Human chromosome 11 affects the expression of fibronectin fibers in human x mouse cell hybrids.
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10. |
Koch GA et al. (1982) Assignment of a fibronection gene to human chromosome 2 using monoclonal antibodies.
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11. |
Niimi K et al. (2002) Fibronectin glomerulopathy with nephrotic syndrome in a 3-year-old male.
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12. |
Kornblihtt AR et al. (1983) Isolation and characterization of cDNA clones for human and bovine fibronectins.
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13. |
Hirano H et al. (1983) Isolation of genomic DNA clones spanning the entire fibronectin gene.
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14. |
Kurkinen M et al. (1980) Polypeptides of human plasma fibronectin are similar but not identical.
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15. |
None (1981) Fibronectin and its role in connective tissue diseases.
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16. |
Rennard SI et al. (1981) Localization of the human fibronectin (FN) gene on chromosome 8 by a specific enzyme immunoassay.
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17. |
None (1981) Fibronectin. A molecular glue.
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18. |
Mosesson MW et al. (1980) The structure and biologic activities of plasma fibronectin.
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19. |
Zardi L et al. (1982) Species-specific monoclonal antibodies in the assignment of the gene for human fibronectin to chromosome 2.
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20. |
Wu BL et al. (1993) In situ hybridization applied to Waardenburg syndrome.
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21. |
Skow LC et al. (1987) Mapping of the mouse fibronectin gene (Fn-1) to chromosome 1: conservation of the Idh-1-Cryg-Fn-1 synteny group in mammals.
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22. |
Bing DH et al. (1982) Fibronectin binds to the C1q component of complement.
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23. |
Mazzucco G et al. (1992) Glomerulonephritis with organized deposits: a mesangiopathic, not immune complex-mediated disease? A pathologic study of two cases in the same family.
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24. |
Castelletti F et al. (2008) Mutations in FN1 cause glomerulopathy with fibronectin deposits.
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25. |
Assmann KJ et al. (1995) Familial glomerulonephritis characterized by massive deposits of fibronectin.
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26. |
Matsunaga T et al. (2003) Interaction between leukemic-cell VLA-4 and stromal fibronectin is a decisive factor for minimal residual disease of acute myelogenous leukemia.
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27. |
None (2000) Molecular switches in metastasis.
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28. |
Clark EA et al. (2000) Genomic analysis of metastasis reveals an essential role for RhoC.
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29. |
Bittner M et al. (2000) Molecular classification of cutaneous malignant melanoma by gene expression profiling.
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30. |
Sakai T et al. (2001) Plasma fibronectin supports neuronal survival and reduces brain injury following transient focal cerebral ischemia but is not essential for skin-wound healing and hemostasis.
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31. |
Liao YF et al. (2002) The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing.
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32. |
Schwarz-Linek U et al. (2003) Pathogenic bacteria attach to human fibronectin through a tandem beta-zipper.
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33. |
Sakai T et al. (2003) Fibronectin requirement in branching morphogenesis.
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34. |
Muro AF et al. (2003) Regulated splicing of the fibronectin EDA exon is essential for proper skin wound healing and normal lifespan.
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35. |
Jiang G et al. (2003) Two-piconewton slip bond between fibronectin and the cytoskeleton depends on talin.
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36. |
Grau S et al. (2006) The role of human HtrA1 in arthritic disease.
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37. |
Owerbach D et al. (1978) Genetics of the large, external, transformation-sensitive (LETS) protein: assignment of a gene coding for expression of LETS to human chromosome 8.
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38. |
Matsuura H et al. (1988) The oncofetal structure of human fibronectin defined by monoclonal antibody FDC-6. Unique structural requirement for the antigenic specificity provided by a glycosylhexapeptide.
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39. |
Kornblihtt AR et al. (1985) Primary structure of human fibronectin: differential splicing may generate at least 10 polypeptides from a single gene.
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40. |
Orphanet article
Orphanet ID 159592
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NCBI article
NCBI 2335
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OMIM.ORG article
Omim 135600
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43. |
Wikipedia article
Wikipedia EN (Fibronectin)
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Update: Aug. 14, 2020