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Integrin alpha-2

The ITGA2 gene encodes a transmembane protein that binds collagen, stabilizes the extracellular matrix, and is involved in platelet aggregation. Mutations cause autosomal dominant platelet-type bleeding disorder 9.


Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA
Clinic Method Target mutation analysis
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Bleeding disorder platelet-type 9
Glycoprotein 1a deficiency



Nieuwenhuis HK et al. () Human blood platelets showing no response to collagen fail to express surface glycoprotein Ia.

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Inoue O et al. (2003) Integrin alpha2beta1 mediates outside-in regulation of platelet spreading on collagen through activation of Src kinases and PLCgamma2.

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von Beckerath N et al. (2000) Glycoprotein Ia gene C807T polymorphism and risk for major adverse cardiac events within the first 30 days after coronary artery stenting.

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Santoso S et al. (1999) A point mutation Thr(799)Met on the alpha(2) integrin leads to the formation of new human platelet alloantigen Sit(a) and affects collagen-induced aggregation.

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Carlsson LE et al. (1999) The alpha2 gene coding sequence T807/A873 of the platelet collagen receptor integrin alpha2beta1 might be a genetic risk factor for the development of stroke in younger patients.

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Santoso S et al. (1999) Association of the platelet glycoprotein Ia C807T gene polymorphism with nonfatal myocardial infarction in younger patients.

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Kritzik M et al. (1998) Nucleotide polymorphisms in the alpha2 gene define multiple alleles that are associated with differences in platelet alpha2 beta1 density.

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Kunicki TJ et al. (1997) Hereditary variation in platelet integrin alpha 2 beta 1 density is associated with two silent polymorphisms in the alpha 2 gene coding sequence.

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Kiefel V et al. (1988) A new platelet-specific alloantigen Bra. Report of 4 cases with neonatal alloimmune thrombocytopenia.

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Woods VL et al. (1989) Antigenic polymorphism of human very late activation protein-2 (platelet glycoprotein Ia-IIa). Platelet alloantigen Hca.

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Mueller-Eckhardt C et al. (1989) 348 cases of suspected neonatal alloimmune thrombocytopenia.

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Takada Y et al. (1989) The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.

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Kiefel V et al. (1991) Neonatal alloimmune thrombocytopenia due to anti-Brb (HPA-5a). Report of three cases in two families.

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Bettaieb A et al. (1991) Brb, a platelet alloantigen involved in neonatal alloimmune thrombocytopenia.

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Kaplan C et al. (1991) HPA-5b (Br(a)) neonatal alloimmune thrombocytopenia: clinical and immunological analysis of 39 cases.

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Jaspers M et al. (1991) Localization of the gene encoding the alpha 2 subunit of the human VLA-2 receptor to chromosome 5q23-31.

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Noris P et al. (2006) Autosomal dominant thrombocytopenias with reduced expression of glycoprotein Ia.

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Santoso S et al. (1993) The human platelet alloantigens Br(a) and Brb are associated with a single amino acid polymorphism on glycoprotein Ia (integrin subunit alpha 2).

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Orphanet article

Orphanet ID 328915 external link

NCBI article

NCBI 3673 external link

OMIM.ORG article

Omim 192974 external link

Wikipedia article

Wikipedia EN (Integrin_alpha_2) external link
Update: Aug. 14, 2020
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