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Complement receptor type 2

The CR2 gene encodes a complement receptor expressed on B lymphocytes which also binds Epstein-Barr virus. Mutations cause autosomal recessive variable immunodeficiency type 7 and susceptibility to lupus erythematodes.


Research Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Systemic lupus erythematosus susceptibility to 9
Variable immunodeficiency type 7



Weis JH et al. (1987) A complement receptor locus: genes encoding C3b/C4b receptor and C3d/Epstein-Barr virus receptor map to 1q32.

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Barrington RA et al. (2009) Uncoupling CD21 and CD19 of the B-cell coreceptor.

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Asokan R et al. (2006) Characterization of human complement receptor type 2 (CR2/CD21) as a receptor for IFN-alpha: a potential role in systemic lupus erythematosus.

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Prota AE et al. (2002) The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding.

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Szakonyi G et al. (2001) Structure of complement receptor 2 in complex with its C3d ligand.

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Weis JJ et al. (1984) Identification of a 145,000 Mr membrane protein as the C3d receptor (CR2) of human B lymphocytes.

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Rodriguez de Cordoba S et al. (1986) Quantitative variations of the C3b/C4b receptor (CR1) in human erythrocytes are controlled by genes within the regulator of complement activation (RCA) gene cluster.

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Moore MD et al. (1987) Molecular cloning of the cDNA encoding the Epstein-Barr virus/C3d receptor (complement receptor type 2) of human B lymphocytes.

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Yefenof E et al. (1976) Surface markers on human B and T-lymphocytes. IX. Two-color immunofluorescence studies on the association between ebv receptors and complement receptors on the surface of lymphoid cell lines.

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Thiel J et al. (2012) Genetic CD21 deficiency is associated with hypogammaglobulinemia.

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Wu H et al. (2007) Association of a common complement receptor 2 haplotype with increased risk of systemic lupus erythematosus.

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Fairweather D et al. (2006) Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyopathy, and heart failure by increasing macrophages, IL-1beta, and immune complex deposition in the heart.

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Rodriguez de Cordoba S et al. (1985) Human genes for three complement components that regulate the activation of C3 are tightly linked.

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Orphanet article

Orphanet ID 160142 external link

NCBI article

NCBI 1380 external link

OMIM.ORG article

Omim 120650 external link

Wikipedia article

Wikipedia EN (Complement_receptor_2) external link
Update: Aug. 14, 2020
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