PPARG cofactor 1-beta
The PPARGC1B encodes a protein that is involved in PPARG based transcription control. Mutations can contribute to obesity in an autosomal domminant fashion.
Genetests:
Related Diseases:
References:
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Lin J et al. (2005) Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP.
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Sahin E et al. (2011) Telomere dysfunction induces metabolic and mitochondrial compromise.
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Andersen G et al. (2005) Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity.
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Lin J et al. (2002) Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor.
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Kressler D et al. (2002) The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha.
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Hentschke M et al. (2002) PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma.
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Kamei Y et al. (2003) PPARgamma coactivator 1beta/ERR ligand 1 is an ERR protein ligand, whose expression induces a high-energy expenditure and antagonizes obesity.
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Ling C et al. (2004) Multiple environmental and genetic factors influence skeletal muscle PGC-1alpha and PGC-1beta gene expression in twins.
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Lai L et al. (2008) Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart.
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Ishii KA et al. (2009) Coordination of PGC-1beta and iron uptake in mitochondrial biogenesis and osteoclast activation.
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Srivastava S et al. (2009) PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders.
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NCBI article
NCBI 133522
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OMIM.ORG article
Omim 608886
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Wikipedia article
Wikipedia EN (PPARGC1B)
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Update: Aug. 14, 2020