Roundabout homolog 2
The ROBO2 gene encodes a transmembrane receptor. Mutations cause vesicoureteral reflux 2.
Genetests:
Related Diseases:
References:
| 1. |
Lu W et al. (2007) Disruption of ROBO2 is associated with urinary tract anomalies and confers risk of vesicoureteral reflux.
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| 2. |
Kidd T et al. (1998) Roundabout controls axon crossing of the CNS midline and defines a novel subfamily of evolutionarily conserved guidance receptors.
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| 3. |
Nagase T et al. (2000) Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.
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| 4. |
Fricke C et al. (2001) astray, a zebrafish roundabout homolog required for retinal axon guidance.
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| 5. |
Bagri A et al. (2002) Slit proteins prevent midline crossing and determine the dorsoventral position of major axonal pathways in the mammalian forebrain.
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| 6. |
Grieshammer U et al. (2004) SLIT2-mediated ROBO2 signaling restricts kidney induction to a single site.
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| 7. |
Yue Y et al. (2006) Isolation and differential expression of two isoforms of the ROBO2/Robo2 axon guidance receptor gene in humans and mice.
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| 8. |
Xiao T et al. (2011) Assembly of lamina-specific neuronal connections by slit bound to type IV collagen.
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| 9. |
NCBI article
NCBI 6092
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| 10. |
OMIM.ORG article
Omim 602431
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| 11. |
Orphanet article
Orphanet ID 289371
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| 12. |
Wikipedia article
Wikipedia EN (ROBO2)
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Update: June 23, 2025