Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The WNT5A gene encodes a secreted signal protein which is involved in oncogenesis and deveopment. Mutations cause autosomal dominant Robinow syndrome 1 characterized by multiple malformations.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Robinow M et al. (1969) A newly recognized dwarfing syndrome. 
|
| 2. |
Miyamoto DT et al. (2015) RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance.
|
| 3. |
Florian MC et al. (2013) A canonical to non-canonical Wnt signalling switch in haematopoietic stem-cell ageing.
|
| 4. |
Miyoshi H et al. (2012) Wnt5a potentiates TGF-β signaling to promote colonic crypt regeneration after tissue injury.
|
| 5. |
Stefater JA et al. (2011) Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells.
|
| 6. |
Ford CE et al. (2009) Wnt-5a signaling restores tamoxifen sensitivity in estrogen receptor-negative breast cancer cells.
|
| 7. |
Witze ES et al. (2008) Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors.
|
| 8. |
Zhang X et al. (2007) Dishevelled promotes axon differentiation by regulating atypical protein kinase C.
|
| 9. |
Schleiffarth JR et al. (2007) Wnt5a is required for cardiac outflow tract septation in mice.
|
| 10. |
Mikels AJ et al. (2006) Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context.
|
| 11. |
Yamaguchi TP et al. (1999) A Wnt5a pathway underlies outgrowth of multiple structures in the vertebrate embryo.
|
| 12. |
He X et al. (1997) A member of the Frizzled protein family mediating axis induction by Wnt-5A.
|
| 13. |
Clark CC et al. (1993) Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21.
|
| 14. |
Gavin BJ et al. (1990) Expression of multiple novel Wnt-1/int-1-related genes during fetal and adult mouse development.
|
| 15. |
Roifman M et al. (2015) De novo WNT5A-associated autosomal dominant Robinow syndrome suggests specificity of genotype and phenotype.
|
| 16. |
Person AD et al. (2010) WNT5A mutations in patients with autosomal dominant Robinow syndrome.
|
| 17. |
Oishi I et al. (2003) The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway.
|
| 18. |
Kuss P et al. (2014) Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A.
|
| 19. |
NCBI article NCBI 7474
|
| 20. |
OMIM.ORG article Omim 164975
|
| 21. |
Orphanet article Orphanet ID 231387
|
| 22. |
Wikipedia article Wikipedia EN (WNT5A)
|
 |
Copyright © 2005-2024 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944 Sitemap | Webmail | Disclaimer | Privacy Issues | Website Credits |
