Insulin-like growth factor-binding protein 3
The IGFBP3 gene encodes a protein that interacts with IGF and prolonges its half-life. Therefore a posible role in growth regulations is hypothized.
Genetests:
Related Diseases:
References:
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Ehrenborg E et al. (1992) Contiguous localization of the genes encoding human insulin-like growth factor binding proteins 1 (IGBP1) and 3 (IGBP3) on chromosome 7.
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Lofqvist C et al. (2007) IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth.
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Chang KH et al. (2007) IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development.
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Cheng I et al. (2007) Genetic determinants of circulating insulin-like growth factor (IGF)-I, IGF binding protein (BP)-1, and IGFBP-3 levels in a multiethnic population.
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Spoerri PE et al. (2003) Expression of IGFBP-3 by human retinal endothelial cell cultures: IGFBP-3 involvement in growth inhibition and apoptosis.
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Spagnoli A et al. (2002) Identification of STAT-1 as a molecular target of IGFBP-3 in the process of chondrogenesis.
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Buckway CK et al. (2001) Mutation of three critical amino acids of the N-terminal domain of IGF-binding protein-3 essential for high affinity IGF binding.
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Popovici RM et al. (2001) Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency.
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Weinzimer SA et al. (2001) Transferrin is an insulin-like growth factor-binding protein-3 binding protein.
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Deal C et al. (2001) Novel promoter polymorphism in insulin-like growth factor-binding protein-3: correlation with serum levels and interaction with known regulators.
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Fraser HM et al. (2000) Changes in insulin-like growth factor-binding protein-3 messenger ribonucleic acid in endothelial cells of the human corpus luteum: a possible role in luteal development and rescue.
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Ferry RJ et al. (1999) Insulin-like growth factor binding proteins: new proteins, new functions.
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Ballard J et al. (1989) On the nomenclature of the IGF binding proteins.
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14. |
Wood WI et al. (1988) Cloning and expression of the growth hormone-dependent insulin-like growth factor-binding protein.
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15. |
Geary MP et al. (2003) Sexual dimorphism in the growth hormone and insulin-like growth factor axis at birth.
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16. |
NCBI article
NCBI 3486
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17. |
OMIM.ORG article
Omim 146732
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18. |
Wikipedia article
Wikipedia EN (IGFBP3)
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Update: Aug. 14, 2020