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Atrial natriuretic peptide-converting enzyme

The CORIN gene encodes a serine protease that activates atrial natriuretic peptide in cardiac myocytes. Some mutations have been associated with preeclampsia 5.


Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Preeclampsia 5



Dries DL et al. (2005) Corin gene minor allele defined by 2 missense mutations is common in blacks and associated with high blood pressure and hypertension.

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Wang W et al. (2008) Corin variant associated with hypertension and cardiac hypertrophy exhibits impaired zymogen activation and natriuretic peptide processing activity.

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Dong N et al. (2013) Corin mutation R539C from hypertensive patients impairs zymogen activation and generates an inactive alternative ectodomain fragment.

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Pan J et al. (2002) Genomic structures of the human and murine corin genes and functional GATA elements in their promoters.

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Knappe S et al. (2003) Functional analysis of the transmembrane domain and activation cleavage of human corin: design and characterization of a soluble corin.

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Guipponi M et al. (2008) An integrated genetic and functional analysis of the role of type II transmembrane serine proteases (TMPRSSs) in hearing loss.

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Cui Y et al. (2012) Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy.

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Dong N et al. (2014) Corin mutations K317E and S472G from preeclamptic patients alter zymogen activation and cell surface targeting. [Corrected].

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Yan W et al. (1999) Corin, a mosaic transmembrane serine protease encoded by a novel cDNA from human heart.

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Yan W et al. (2000) Corin, a transmembrane cardiac serine protease, acts as a pro-atrial natriuretic peptide-converting enzyme.

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NCBI article

NCBI 10699 external link

OMIM.ORG article

Omim 605236 external link

Orphanet article

Orphanet ID 434292 external link

Wikipedia article

Wikipedia EN (CORIN) external link
Update: Aug. 14, 2020
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