Interleukin-36 receptor antagonist protein
The IL36RN gene encodes a cytokin that belongs to the interleukin 1 family. Mutations cause severe pustular forms of psoriasis (pustular psoriasis 14 and DITRA disease).
Genetests:
Related Diseases:
References:
| 1. |
Nicklin MJ et al. (2002) A sequence-based map of the nine genes of the human interleukin-1 cluster.
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| 2. |
Mulero JJ et al. (1999) IL1HY1: A novel interleukin-1 receptor antagonist gene.
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| 3. |
Smith DE et al. (2000) Four new members expand the interleukin-1 superfamily.
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| 4. |
Busfield SJ et al. (2000) Identification and gene organization of three novel members of the IL-1 family on human chromosome 2.
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| 5. |
Johnston A et al. (2011) IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression.
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| 6. |
Onoufriadis A et. al. (2011) Mutations in IL36RN/IL1F5 are associated with the severe episodic inflammatory skin disease known as generalized pustular psoriasis.
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| 7. |
Marrakchi S et al. (2011) Interleukin-36-receptor antagonist deficiency and generalized pustular psoriasis.
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| 8. |
Sugiura K et al. (2012) A novel IL36RN/IL1F5 homozygous nonsense mutation, p.Arg10X, in a Japanese patient with adult-onset generalized pustular psoriasis.
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| 9. |
Farooq M et. al. (2013) Mutation analysis of the IL36RN gene in 14 Japanese patients with generalized pustular psoriasis.
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| 10. |
Setta-Kaffetzi N et al. (2013) Rare pathogenic variants in IL36RN underlie a spectrum of psoriasis-associated pustular phenotypes.
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| 11. |
Krber A et. al. (2013) Mutations in IL36RN in patients with generalized pustular psoriasis.
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| 12. |
Sugiura K et al. (2013) The majority of generalized pustular psoriasis without psoriasis vulgaris is caused by deficiency of interleukin-36 receptor antagonist.
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| 13. |
Berki DM et. al. (2014) Loss of IL36RN function does not confer susceptibility to psoriasis vulgaris.
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| 14. |
Li M et. al. (2013) Prevalent and rare mutations in IL-36RN gene in Chinese patients with generalized pustular psoriasis and psoriasis vulgaris.
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Update: June 23, 2025