Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Macrophage migration inhibitory factor

The MIF gene encodes a cytokine which is involved in immune regulation and inflammation. Genetic variants influences the susceptibility to juvenile arthritis.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Systemic-onset juvenile idiopathic arthritis
IL6
LACC1
MIF

References:

1.

Pastrana DV et al. (1998) Filarial nematode parasites secrete a homologue of the human cytokine macrophage migration inhibitory factor.

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2.

Miller EJ et al. (2008) Macrophage migration inhibitory factor stimulates AMP-activated protein kinase in the ischaemic heart.

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3.

Arjona A et al. (2007) Abrogation of macrophage migration inhibitory factor decreases West Nile virus lethality by limiting viral neuroinvasion.

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4.

Bernhagen J et al. (2007) MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment.

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5.

Wang B et al. (2006) Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses.

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6.

Amin MA et al. (2003) Migration inhibitory factor mediates angiogenesis via mitogen-activated protein kinase and phosphatidylinositol kinase.

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7.

De Benedetti F et. al. (2003) Functional and prognostic relevance of the -173 polymorphism of the macrophage migration inhibitory factor gene in systemic-onset juvenile idiopathic arthritis.

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8.

Donn R et. al. (2002) Mutation screening of the macrophage migration inhibitory factor gene: positive association of a functional polymorphism of macrophage migration inhibitory factor with juvenile idiopathic arthritis.

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9.

Koebernick H et al. (2002) Macrophage migration inhibitory factor (MIF) plays a pivotal role in immunity against Salmonella typhimurium.

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10.

Roger T et al. () MIF regulates innate immune responses through modulation of Toll-like receptor 4.

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11.

Donn RP et. al. (2001) A novel 5'-flanking region polymorphism of macrophage migration inhibitory factor is associated with systemic-onset juvenile idiopathic arthritis.

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12.

Kleemann R et al. (2000) Intracellular action of the cytokine MIF to modulate AP-1 activity and the cell cycle through Jab1.

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13.

Weiser WY et al. (1989) Molecular cloning of a cDNA encoding a human macrophage migration inhibitory factor.

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14.

Esumi N et al. (1998) Conserved gene structure and genomic linkage for D-dopachrome tautomerase (DDT) and MIF.

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15.

Rossi AG et al. (1998) Human circulating eosinophils secrete macrophage migration inhibitory factor (MIF). Potential role in asthma.

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16.

Budarf M et al. (1997) Localization of the human gene for macrophage migration inhibitory factor (MIF) to chromosome 22q11.2.

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17.

None (1996) MIF rediscovered: cytokine, pituitary hormone, and glucocorticoid-induced regulator of the immune response.

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18.

Bernhagen J et al. (1993) MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia.

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19.

Paralkar V et al. (1994) Cloning the human gene for macrophage migration inhibitory factor (MIF).

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20.

Bozza M et al. (1995) Structural characterization and chromosomal location of the mouse macrophage migration inhibitory factor gene and pseudogenes.

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21.

Kozak CA et al. (1995) Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.

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22.

Bloom BR et al. (1966) Mechanism of a reaction in vitro associated with delayed-type hypersensitivity.

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23.

None (1966) Delayed hypersensitivity in vitro: its mediation by cell-free substances formed by lymphoid cell-antigen interaction.

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Update: Aug. 14, 2020
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