Disintegrin and metalloproteinase domain-containing protein 17
The ADAM17 gene encodes an ADAM protein (disintegrin and metalloprotease domain-containig) wich is involved in cell and cell matrix interactions. Mutation cause a prediposition to autoinflammatory diseases such as neanatal inflammatory skin and bowel disease type 1.
Genetests:
Related Diseases:
References:
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Mohan MJ et al. (2002) The tumor necrosis factor-alpha converting enzyme (TACE): a unique metalloproteinase with highly defined substrate selectivity.
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Künzel U et al. (2018) FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex.
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Oikonomidi I et al. (2018) iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE.
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Brooke MA et al. (2014) iRHOM2-dependent regulation of ADAM17 in cutaneous disease and epidermal barrier function.
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McIlwain DR et al. (2012) iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS.
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Adrain C et al. (2012) Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.
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Blaydon DC et al. (2011) Inflammatory skin and bowel disease linked to ADAM17 deletion.
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Chen CD et al. (2007) Insulin stimulates the cleavage and release of the extracellular domain of Klotho by ADAM10 and ADAM17.
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Horiuchi K et al. (2007) Cutting edge: TNF-alpha-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock.
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Asai M et al. (2003) Putative function of ADAM9, ADAM10, and ADAM17 as APP alpha-secretase.
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Black RA et al. (1997) A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells.
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Garton KJ et al. (2001) Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates the cleavage and shedding of fractalkine (CX3CL1).
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Brou C et al. (2000) A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE.
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Nelson KK et al. (1999) Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta.
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Peschon JJ et al. (1998) An essential role for ectodomain shedding in mammalian development.
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Hirohata S et al. (1998) Chromosomal assignment of two ADAM genes, TACE (ADAM17) and MLTNB (ADAM19), to human chromosomes 2 and 5, respectively, and of Mltnb to mouse chromosome 11.
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Yamazaki K et al. (1998) Genetic mapping of mouse tumor necrosis factor-alpha converting enzyme (TACE) to chromosome 12.
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Patel IR et al. (1998) TNF-alpha convertase enzyme from human arthritis-affected cartilage: isolation of cDNA by differential display, expression of the active enzyme, and regulation of TNF-alpha.
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Moss ML et al. (1997) Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
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20. |
Diwan A et al. (2004) Targeted overexpression of noncleavable and secreted forms of tumor necrosis factor provokes disparate cardiac phenotypes.
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Update: Aug. 14, 2020