Interleukin-2 receptor subunit alpha
The IL2RA gene encodes a component of an interleukin receptor. Mutations cause autosomal recessive immunodeficiency 41 and are associated with type 1 diabetes.
Genetests:
Related Diseases:
References:
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Rickert M et al. (2005) The structure of interleukin-2 complexed with its alpha receptor.
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Urdal DL et al. (1984) Purification and chemical characterization of the receptor for interleukin 2 from activated human T lymphocytes and from a human T-cell lymphoma cell line.
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Asano M et al. (1996) Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation.
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Sharfe N et al. (1997) Human immune disorder arising from mutation of the alpha chain of the interleukin-2 receptor.
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None (2001) Certified professionals: CD4(+)CD25(+) suppressor T cells.
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Lamaze C et al. (2001) Interleukin 2 receptors and detergent-resistant membrane domains define a clathrin-independent endocytic pathway.
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8. |
Hori S et al. (2003) Control of regulatory T cell development by the transcription factor Foxp3.
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9. |
Vella A et al. (2005) Localization of a type 1 diabetes locus in the IL2RA/CD25 region by use of tag single-nucleotide polymorphisms.
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10. |
Leonard WJ et al. (1983) Characterization of the human receptor for T-cell growth factor.
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11. |
Wang X et al. (2005) Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors.
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12. |
Caudy AA et al. (2007) CD25 deficiency causes an immune dysregulation, polyendocrinopathy, enteropathy, X-linked-like syndrome, and defective IL-10 expression from CD4 lymphocytes.
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13. |
Lowe CE et al. (2007) Large-scale genetic fine mapping and genotype-phenotype associations implicate polymorphism in the IL2RA region in type 1 diabetes.
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14. |
Goudy K et al. (2013) Human IL2RA null mutation mediates immunodeficiency with lymphoproliferation and autoimmunity.
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15. |
Bezrodnik L et al. (2014) Follicular bronchiolitis as phenotype associated with CD25 deficiency.
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16. |
Li J et al. (2016) EBI2 augments Tfh cell fate by promoting interaction with IL-2-quenching dendritic cells.
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17. |
Simeonov DR et al. (2017) Discovery of stimulation-responsive immune enhancers with CRISPR activation.
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20. |
Webb GC et al. (1990) Mapping the gene for murine T-cell growth factor, Il-2, to bands B-C on chromosome 3 and for the alpha chain of the IL2-receptor, Il-2ra, to bands A2-A3 on chromosome 2.
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21. |
Leonard WJ et al. (1985) Structure of the human interleukin-2 receptor gene.
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22. |
Ishida N et al. (1985) Molecular cloning and structure of the human interleukin 2 receptor gene.
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23. |
Greene WC et al. (1986) The human interleukin-2 receptor: normal and abnormal expression in T cells and in leukemias induced by the human T-lymphotropic retroviruses.
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24. |
Kondo S et al. () Expression of functional human interleukin-2 receptor in mouse T cells by cDNA transfection.
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25. |
Hatakeyama M et al. (1986) Intracytoplasmic phosphorylation sites of Tac antigen (p55) are not essential for the conformation, function, and regulation of the human interleukin 2 receptor.
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26. |
Tsudo M et al. (1986) Demonstration of a non-Tac peptide that binds interleukin 2: a potential participant in a multichain interleukin 2 receptor complex.
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27. |
Pasare C et al. (2003) Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells.
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28. |
Ferrari S et al. (1987) The gene encoding human vimentin is located on the short arm of chromosome 10.
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29. |
Leonard WJ et al. (1985) Localization of the gene encoding the human interleukin-2 receptor on chromosome 10.
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30. |
Hatakeyama M et al. () Reconstitution of functional receptor for human interleukin-2 in mouse cells.
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31. |
Leonard WJ et al. () Molecular cloning and expression of cDNAs for the human interleukin-2 receptor.
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32. |
Nikaido T et al. () Molecular cloning of cDNA encoding human interleukin-2 receptor.
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33. |
None (1984) The interleukin-2 receptor gene is cloned.
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34. |
Cosman D et al. () Cloning, sequence and expression of human interleukin-2 receptor.
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Update: Aug. 14, 2020