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C-type lectin domain family 7 member A

The CLEC7A gene encodes a C-type lectin protein, also known as dectin-1. It is an extracellular pathogen pattern receptor that binds beta-glucan, a polysacharide predominantly found in pathogenic fungi. Deficiencies cause severe fungal infections.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Genetic susceptibility to aspergillosis
CLEC1A
CLEC7A
Familial candidiasis 4
CLEC7A

References:

1.

Xie J et al. (2006) Human Dectin-1 isoform E is a cytoplasmic protein and interacts with RanBPM.

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2.

Lefèvre L et al. (2013) The C-type lectin receptors dectin-1, MR, and SIGNR3 contribute both positively and negatively to the macrophage response to Leishmania infantum.

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3.

Iliev ID et al. (2012) Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis.

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4.

Gringhuis SI et al. (2012) Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.

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5.

Lee HM et al. (2012) Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin-1-Syk and p62/SQSTM1.

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6.

Goodridge HS et al. (2011) Activation of the innate immune receptor Dectin-1 upon formation of a 'phagocytic synapse'.

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7.

Cunha C et al. (2010) Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity.

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8.

Maródi L et al. (2010) Dectin-1 deficiency and mucocutaneous fungal infections.

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9.

Ferwerda B et al. (2009) Human dectin-1 deficiency and mucocutaneous fungal infections.

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10.

Glocker EO et al. (2009) A homozygous CARD9 mutation in a family with susceptibility to fungal infections.

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11.

Taylor PR et al. (2007) Dectin-1 is required for beta-glucan recognition and control of fungal infection.

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12.

Saijo S et al. (2007) Dectin-1 is required for host defense against Pneumocystis carinii but not against Candida albicans.

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13.

Ku CL et al. (2007) IRAK4 and NEMO mutations in otherwise healthy children with recurrent invasive pneumococcal disease.

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14.

Gross O et al. (2006) Card9 controls a non-TLR signalling pathway for innate anti-fungal immunity.

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15.

Brown GD et al. (2003) Dectin-1 mediates the biological effects of beta-glucans.

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16.

Willment JA et al. (2001) Characterization of the human beta -glucan receptor and its alternatively spliced isoforms.

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17.

Brown GD et al. (2001) Immune recognition. A new receptor for beta-glucans.

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18.

Hermanz-Falcón P et al. () Cloning of human DECTIN-1, a novel C-type lectin-like receptor gene expressed on dendritic cells.

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19.

Yokota K et al. (2001) Identification of a human homologue of the dendritic cell-associated C-type lectin-1, dectin-1.

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20.

Ariizumi K et al. (2000) Identification of a novel, dendritic cell-associated molecule, dectin-1, by subtractive cDNA cloning.

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21.

Hise AG et al. (2009) An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans.

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22.

Manicassamy S et al. (2009) Toll-like receptor 2-dependent induction of vitamin A-metabolizing enzymes in dendritic cells promotes T regulatory responses and inhibits autoimmunity.

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23.

von Bernuth H et al. (2008) Pyogenic bacterial infections in humans with MyD88 deficiency.

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Update: Aug. 14, 2020
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