Toll-like receptor 3
The TLR3 gene encodes a toll-like receptor which as an important component of innate immunity senses double stranded RNA in phagolysosomes. Mutations cause susceptibility to Herpes encephalitis and COVID-19.
Genetests:
Related Diseases:
References:
| 1. |
Yang Z et al. (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration.
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| 2. |
Mørk N et al. (2015) Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
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| 3. |
Hu YH et al. (2015) WDFY1 mediates TLR3/4 signaling by recruiting TRIF.
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| 4. |
Lim HK et al. (2014) TLR3 deficiency in herpes simplex encephalitis: high allelic heterogeneity and recurrence risk.
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| 5. |
Verstak B et al. (2013) An alanine-to-proline mutation in the BB-loop of TLR3 Toll/IL-1R domain switches signalling adaptor specificity from TRIF to MyD88.
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| 6. |
Gorbea C et al. (2013) Depletion of the 26S proteasome adaptor Ecm29 increases Toll-like receptor 3 signaling.
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| 7. |
Zhang SY et al. (2013) TLR3 immunity to infection in mice and humans.
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| 8. |
Sironi M et al. (2012) A common polymorphism in TLR3 confers natural resistance to HIV-1 infection.
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| 9. |
Guo Y et al. (2011) Herpes simplex virus encephalitis in a patient with complete TLR3 deficiency: TLR3 is otherwise redundant in protective immunity.
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| 10. |
Ives A et al. (2011) Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis.
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| 11. |
Zhou Y et al. (2010) A critical function of toll-like receptor-3 in the induction of anti-human immunodeficiency virus activities in macrophages.
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| 12. |
Bsibsi M et al. (2010) The microtubule regulator stathmin is an endogenous protein agonist for TLR3.
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| 13. |
Lai Y et al. (2009) Commensal bacteria regulate Toll-like receptor 3-dependent inflammation after skin injury.
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| 14. |
Allikmets R et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3.
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| 15. |
Edwards AO et al. (2009) Geographic atrophy in age-related macular degeneration and TLR3.
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| 16. |
None (2009) Geographic atrophy in age-related macular degeneration and TLR3.
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| 17. |
Kadowaki N et al. (2001) Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens.
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| 18. |
Liu L et al. (2008) Structural basis of toll-like receptor 3 signaling with double-stranded RNA.
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| 19. |
Kleinman ME et al. (2008) Sequence- and target-independent angiogenesis suppression by siRNA via TLR3.
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| 20. |
Zhang SY et al. (2007) TLR3 deficiency in patients with herpes simplex encephalitis.
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| 21. |
Bell JK et al. (2006) The dsRNA binding site of human Toll-like receptor 3.
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| 22. |
Choe J et al. (2005) Crystal structure of human toll-like receptor 3 (TLR3) ectodomain.
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| 23. |
Li K et al. (2005) Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes.
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| 24. |
Schulz O et al. (2005) Toll-like receptor 3 promotes cross-priming to virus-infected cells.
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| 25. |
Meylan E et al. (2004) RIP1 is an essential mediator of Toll-like receptor 3-induced NF-kappa B activation.
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| 26. |
Doyle S et al. (2002) IRF3 mediates a TLR3/TLR4-specific antiviral gene program.
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| 27. |
Alexopoulou L et al. (2001) Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3.
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| 28. |
Zhang Q et al. (2020) Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.
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| 29. |
Muzio M et al. (2000) Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells.
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| 30. |
Rock FL et al. (1998) A family of human receptors structurally related to Drosophila Toll.
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| 31. |
Delgado MF et al. (2009) Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.
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Update: June 23, 2025