Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders

Tarsal-carpal coalition syndrome

Tarsal-carpal coalition syndrome is an autosomal dominant disorder caused by mutations of the NOG gene. It is characterized by fusion of the carpals, tarsals, and phalanges.


Inborn skeletal malformations
Al-Gazali-Bakalinova syndrome
Branchio-oculo-facial syndrome
Congenital contractural arachnodactyly
Ehlers-Danlos syndrome due to tenascin-X deficiency
Hydrolethalus 2
Lacrimoauriculodentodigital syndrome
Multiple synostoses syndrome
Multiple synostoses syndrome 3
Orofacial cleft 11
Orofaciodigital syndrome
Periodontal Ehlers-Danlos syndrome
Proximal symphalangism
Renal tubular acidosis with arthrogryposis
Simpson-Golabi-Behmel syndrome
Stapes ankylosis with broad thumbs and toes
Syndactyly type 5
Synpolydactyly type 1
Tarsal-carpal coalition syndrome
Tatton-Brown-Rahman syndrome
Townes-Brocks syndrome
Trigonocephaly 2
Van Maldergem syndrome 2



Drawbert JP et. al. (1985) Tarsal and carpal coalition and symphalangism of the Fuhrmann type. Report of a family.


Dixon ME et. al. () Identical mutations in NOG can cause either tarsal/carpal coalition syndrome or proximal symphalangism.


Gregersen HN et. al. (1977) Congenital malformation of the feet with low body height. A new syndrome, caused by an autosomal dominant gene.

Update: Sept. 26, 2018