Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
A genetic variation identified in the APOL1 gene causes an increased susceptibility to FSGS but at the same time it helps heterozygous carriers to defend against trypanosoma brucei infections.
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Duchateau PN et al. (2001) Apolipoprotein L gene family: tissue-specific expression, splicing, promoter regions; discovery of a new gene. 
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Page NM et al. (2001) The human apolipoprotein L gene cluster: identification, classification, and sites of distribution.
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Mimmack ML et al. (2002) Gene expression analysis in schizophrenia: reproducible up-regulation of several members of the apolipoprotein L family located in a high-susceptibility locus for schizophrenia on chromosome 22.
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Monajemi H et al. (2002) The apolipoprotein L gene cluster has emerged recently in evolution and is expressed in human vascular tissue.
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Vanhamme L et al. (2003) Apolipoprotein L-I is the trypanosome lytic factor of human serum.
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Pérez-Morga D et al. (2005) Apolipoprotein L-I promotes trypanosome lysis by forming pores in lysosomal membranes.
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Genovese G et al. (2010) Association of trypanolytic ApoL1 variants with kidney disease in African Americans.
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Duchateau PN et al. (1997) Apolipoprotein L, a new human high density lipoprotein apolipoprotein expressed by the pancreas. Identification, cloning, characterization, and plasma distribution of apolipoprotein L.
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OMIM.ORG article Omim 603743
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