The genetic predisposition to to meningococcal meningitis is defined by complement deficiencies in particular of the terminal membrane attack complex (C5-C9). Also complement regulatory protein can be altered, C3, CFH, CFD, and CFP for instance.
Prophylaxis is successful with vaccination.
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6. |
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9. |
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11. |
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12. |
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14. |
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16. |
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17. |
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18. |
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19. |
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20. |
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21. |
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22. |
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24. |
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25. |
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26. |
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27. |
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28. |
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29. |
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30. |
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31. |
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32. |
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33. |
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34. |
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35. |
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36. |
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37. |
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38. |
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39. |
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40. |
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41. |
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42. |
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43. |
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44. |
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45. |
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46. |
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47. |
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48. |
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50. |
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51. |
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52. |
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53. |
Rittner C et al. (1976) Lack of linkage between gene(s) controlling the synthesis of the seventh component of complement and the HLA region on chromosome No. 6 in man. ![]() |
54. |
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55. |
OMIM.ORG article Omim 312060![]() |