Brunner syndrome

Brunner syndrome is an x-linked recessive disordercaused by mutations of the MAOA gene. It is characterized by impulsive aggressiveness and mild mental retardation.

Systematic

Hereditary neurological disorders
	Alzheimer disease
	Arts syndrome
	Ataxia-pancytopenia syndrome
	Autism
	Autosomal dominant cerebellar ataxia, deafness and narcolepsy
	Autosomal recessive spastic paraplegia type 44
	Brain malformations with urinary tract defects
	Brain small vessel disease with hemorrhage
	Brunner syndrome
		MAOA
	Charcot-Marie-Tooth disease
	Congenital insensitivity to pain with anhidrosis
	Epilepsy syndrome
	Hereditary benign chorea
	Hereditary brain tumors
	Hereditary distal motor neuron neuropathy type 5A
	Hereditary muscle diseases
	Hereditary sensory and autonomic neuropathy type 2A
	Hereditary sensory neuropathy type 1E
	Hypokalemic periodic paralysis 1
	Hypomyelinating Leukodystrophy 2
	Idiopathic basal ganglia calcification 1
	Intellectual disability-severe speech delay-mild dysmorphism syndrome
	Migraine
	Nemaline myopathy 5
	Porencephaly
	Rett syndrome
	Severe neonatal-onset encephalopathy with microcephaly
	Spastic paraplegia 17 with amyotrophy of hands and feet
	Susceptibility to glioma
	Tuberous sclerosis complex
	Vascular dementia
	X-linked syndromic mental retardation 13

References:

1.	Brunner HG et al. (1993) Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A.

2.	Brunner HG et al. (1993) X-linked borderline mental retardation with prominent behavioral disturbance: phenotype, genetic localization, and evidence for disturbed monoamine metabolism.

3.	Hebebrand J et al. (1995) Specification of the phenotype required for men with monoamine oxidase type A deficiency.

4.	Orphanet article Orphanet ID 3057

5.	OMIM.ORG article Omim 300615

6.	Wikipedia article Wikipedia EN (Brunner_syndrome)

Update: June 23, 2025

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