Neural precursor cell expressed, developmentally downregulated 4

The protein product of the NEDD4 gene plays an important role in inactivation of the aldosterone-sensitive sodium channel. Dysfunction is associated with Liddle syndrome.

Pathology

The protein contains a WW domain, which binds with the PP.Y domain of the gamma and beta subunits of the aldosterone-sensitive sodium channel (ENaC). This interaction leads to ubiquitylation, internalization, and finally inactivation of the channel.

Genetests:

Related Diseases:

Liddle syndrome
	NEDD4
	NEDD4L
	NR3C2
	OXSR1
	SCNN1B
	SCNN1G
	STK39

References:

1.	Abriel H et al. (1999) Defective regulation of the epithelial Na+ channel by Nedd4 in Liddle's syndrome.

2.	NCBI article NCBI 4734

3.	OMIM.ORG article Omim 602278

4.	Wikipedia article Wikipedia EN (NEDD4)