Serine threonine kinase 39
There gene product is a threonine kinase downstream the signal cascade from WNK kinases to SLC12A cotransporters. Therefor it may play a significant role in regulation of electrolyte excretion in the distal tubule.
Genetests:
Related Diseases:
References:
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Johnston AM et al. (2000) SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.
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2. |
Wang Y et al. (2009) From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.
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3. |
Cunnington MS et al. (2009) STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression.
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4. |
NCBI article
NCBI 27347
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5. |
OMIM.ORG article
Omim 607648
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6. |
Wikipedia article
Wikipedia EN (STK39)
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Update: Aug. 14, 2020