Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
There gene product is a threonine kinase downstream the signal cascade from WNK kinases to SLC12A cotransporters. Therefor it may play a significant role in regulation of electrolyte excretion in the distal tubule.
| Clinic | Method | Carrier testing |
| Turnaround | 5 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Clinic | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| 1. |
Johnston AM et al. (2000) SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. 
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| 2. |
Wang Y et al. (2009) From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.
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| 3. |
Cunnington MS et al. (2009) STK39 polymorphisms and blood pressure: an association study in British Caucasians and assessment of cis-acting influences on gene expression.
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| 4. |
NCBI article NCBI 27347
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| 5. |
OMIM.ORG article Omim 607648
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| 6. |
Wikipedia article Wikipedia EN (STK39)
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