Apolipoprotein A4
This APOA4 gene encodes apolipoprotein A4, a component of HDL particles and chylomicrons. Genetic variations are associated with familial combined hypercholestarolemia.
Gene Structure
APOA1-APOC3-APOA4 gene cluster shows a remarkable linkage disequilibrium, so if we find a disease association of a polymorphism in one of these genes it may be related to a polymorphism in an other of these genes as well.
Genetests:
Research |
Method |
Carrier testing |
Turnaround |
5 days |
Specimen type |
genomic DNA |
Related Diseases:
References:
1. |
von Eckardstein A et al. (1992) Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population.
|
2. |
Cohen RD et al. (1997) Reduced aortic lesions and elevated high density lipoprotein levels in transgenic mice overexpressing mouse apolipoprotein A-IV.
|
3. |
Duverger N et al. (1996) Protection against atherogenesis in mice mediated by human apolipoprotein A-IV.
|
4. |
Menzel HJ et al. (1982) Apolipoprotein A-IV polymorphism in man.
|
5. |
Green PH et al. (1980) Human apolipoprotein A-IV. Intestinal origin and distribution in plasma.
|
6. |
Schamaun O et al. (1984) The two apolipoprotein loci apo A-I and apo A-IV are closely linked in man.
|
7. |
Tracy RP et al. (1982) Two-dimensional gel electrophoresis of serum specimens from a normal population.
|
8. |
None (1985) Apolipoprotein multigene family: tandem organization of human apolipoprotein AI, CIII, and AIV genes.
|
9. |
Kamboh MI et al. (1987) Genetic studies of human apolipoproteins. I. Polymorphism of apolipoprotein A-IV.
|
10. |
Menzel HJ et al. (1988) Human apolipoprotein A-IV polymorphism: frequency and effect on lipid and lipoprotein levels.
|
11. |
Elshourbagy NA et al. (1986) The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III.
|
12. |
Elshourbagy NA et al. (1987) Structure and expression of the human apolipoprotein A-IV gene.
|
13. |
Rogne S et al. (1986) Confirmation of the close linkage between the loci for human apolipoproteins AI and AIV by the use of a cloned cDNA probe and two restriction site polymorphisms.
|
14. |
Lohse P et al. (1990) Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene.
|
15. |
Menzel HJ et al. (1990) Frequency and effect of human apolipoprotein A-IV polymorphism on lipid and lipoprotein levels in an Icelandic population.
|
16. |
Lohse P et al. (1990) Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1.
|
17. |
Kamboh MI et al. (1992) Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism.
|
18. |
Karathanasis SK et al. (1986) Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4).
|
19. |
NCBI article
NCBI 337
|
20. |
OMIM.ORG article
Omim 107690
|
21. |
Wikipedia article
Wikipedia EN (APOA4)
|
Update: Aug. 14, 2020