SLIT-ROBO Rho GTPase-activating protein 1
The SRGAP1-gene encodes a protein that functions as a GTPase activator ind is thereby involved in signal tranduction. Mutations cause autosomal dominant non-medullary thyroid cancer 2.
Genetests:
Related Diseases:
References:
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Nagase T et al. (2000) Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.
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2. |
He H et al. (2013) SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.
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3. |
Wong K et al. (2001) Signal transduction in neuronal migration: roles of GTPase activating proteins and the small GTPase Cdc42 in the Slit-Robo pathway.
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4. |
NCBI article
NCBI 57522
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5. |
OMIM.ORG article
Omim 606523
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6. |
Wikipedia article
Wikipedia EN (SRGAP1)
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Update: Aug. 14, 2020