Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Hereditary non-medullary thyroid cancer 2 is an autosomal dominant disorder caused by mutations of the SRGAP1 and MINPP1 genes. Also in tumors somatic mutation in the genes NRAS and HRAS are found.
| 1. |
He H et al. (2013) SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility. 
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| 2. |
Vriens MR et al. (2009) Clinical features and genetic predisposition to hereditary nonmedullary thyroid cancer.
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| 3. |
Bonora E et al. (2010) Genetic Predisposition to Familial Nonmedullary Thyroid Cancer: An Update of Molecular Findings and State-of-the-Art Studies.
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| 4. |
OMIM.ORG article Omim 188470
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