Cytochrome P450 3A5
The CYP3A5 gene encodes an enzyme from the cytochrome P450 superfamily which is involved in metabolism of steroids (hormones and lipids) and various drugs.
Genetests:
Related Diseases:
References:
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Aoyama T et al. (1989) Cytochrome P-450 hPCN3, a novel cytochrome P-450 IIIA gene product that is differentially expressed in adult human liver. cDNA and deduced amino acid sequence and distinct specificities of cDNA-expressed hPCN1 and hPCN3 for the metabolism of steroid hormones and cyclosporine.
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2. |
Jounaïdi Y et al. (1994) Sequence of the 5'-flanking region of CYP3A5: comparative analysis with CYP3A4 and CYP3A7.
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3. |
Yamakoshi Y et al. (1999) Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein.
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4. |
Paulussen A et al. (2000) Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans.
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Gellner K et al. (2001) Genomic organization of the human CYP3A locus: identification of a new, inducible CYP3A gene.
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6. |
Kuehl P et al. (2001) Sequence diversity in CYP3A promoters and characterization of the genetic basis of polymorphic CYP3A5 expression.
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7. |
Hustert E et al. (2001) The genetic determinants of the CYP3A5 polymorphism.
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8. |
Lin YS et al. (2002) Co-regulation of CYP3A4 and CYP3A5 and contribution to hepatic and intestinal midazolam metabolism.
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9. |
Givens RC et al. (2003) CYP3A5 genotype predicts renal CYP3A activity and blood pressure in healthy adults.
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10. |
Lee SJ et al. (2003) Genetic findings and functional studies of human CYP3A5 single nucleotide polymorphisms in different ethnic groups.
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11. |
Kivistö KT et al. (2004) Lipid-lowering response to statins is affected by CYP3A5 polymorphism.
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12. |
Thompson EE et al. (2004) CYP3A variation and the evolution of salt-sensitivity variants.
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Orphanet article
Orphanet ID 241994
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14. |
NCBI article
NCBI 1577
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15. |
OMIM.ORG article
Omim 605325
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16. |
Wikipedia article
Wikipedia EN (CYP3A5)
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Update: Aug. 14, 2020