Disturbances of vitamin K metabolism

if vitamin K metabolism is disturbed a bleeding disorder similar to wafarin medication ensues. A combined factor II, VII, IX, and X deficiency is observed.

Systematic

Hereditary bleeding disorders
	Afibrinogenemia
	Disturbances of vitamin K metabolism
		Combined deficiency of vitamin K-dependent clotting factors type 1
			GGCX
		Combined deficiency of vitamin K-dependent clotting factors type 2
			VKORC1
		Coumarin resistance
			CYP2A6
			CYP2C9
			CYP4F2
			VKORC1
		Pseudoxanthoma elasticum-like disorder with multiple coagulation factor deficiency
			GGCX
	Dysfibrinogenemia
	Factor XII deficiency
	Factor XIII A subunit deficiency
	Factor XIII B subunit deficiency
	Plasminogen activator inhibitor deficiency

References:

1.	Rost S et al. (2004) Mutations in VKORC1 cause warfarin resistance and multiple coagulation factor deficiency type 2.

2.	Garcia AA et al. (2008) VKORC1 and the vitamin K cycle.

3.	Orphanet article Orphanet ID 93442