Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
The CYP4F2 gene encodes a member of the cytochrome P450 superfamily of enzymes. It is involved in drug metabolism, in particular coumarin derivates.
| Clinic | Method | Massive parallel sequencing |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
| Research | Method | Genomic sequencing of the entire coding region |
| Turnaround | 25 days | |
| Specimen type | genomic DNA |
Disturbances of cytochrome p450 system
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CYP1A2
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CYP2A6
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CYP2C9
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CYP2D6
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CYP3A4
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CYP4F2
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Siponimod intolerance
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CYP2C9
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| 1. |
Caldwell MD et al. (2008) CYP4F2 genetic variant alters required warfarin dose. 
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| 2. |
Kikuta Y et al. (1999) Expression and molecular cloning of human liver leukotriene B4 omega-hydroxylase (CYP4F2) gene.
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| 3. |
Stec DE et al. (2007) Functional polymorphism in human CYP4F2 decreases 20-HETE production.
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| 4. |
Orphanet article Orphanet ID 286575
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| 5. |
NCBI article NCBI 8529
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| 6. |
OMIM.ORG article Omim 604426
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| 7. |
Wikipedia article Wikipedia EN (CYP4F2)
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