Cytochrome P450 1A2
The CYP2D6 gene encodes a member of the cytochrome P450 superfamily. It metabolizes many pharmaceuticals.
Interpretation
This enzyme is induced in smokers, so the metabolic rate of substances may be increased by 36-38% in smokers.
Genetests:
Related Diseases:
References:
1. |
Schweikl H et al. (1993) Expression of CYP1A1 and CYP1A2 genes in human liver.
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2. |
Browning SL et al. (2010) CYP1A2 is more variable than previously thought: a genomic biography of the gene behind the human drug-metabolizing enzyme.
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3. |
Wooding SP et al. (2002) DNA sequence variation in a 3.7-kb noncoding sequence 5' of the CYP1A2 gene: implications for human population history and natural selection.
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4. |
Rasmussen BB et al. (2002) The interindividual differences in the 3-demthylation of caffeine alias CYP1A2 is determined by both genetic and environmental factors.
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5. |
Christiansen L et al. (2000) Association between CYP1A2 polymorphism and susceptibility to porphyria cutanea tarda.
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6. |
Tantcheva-Poór I et al. (1999) Estimation of cytochrome P-450 CYP1A2 activity in 863 healthy Caucasians using a saliva-based caffeine test.
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7. |
Sachse C et al. (1999) Functional significance of a C-->A polymorphism in intron 1 of the cytochrome P450 CYP1A2 gene tested with caffeine.
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8. |
Nakajima M et al. (1999) Genetic polymorphism in the 5'-flanking region of human CYP1A2 gene: effect on the CYP1A2 inducibility in humans.
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9. |
Buters JT et al. (1996) Role of CYP1A2 in caffeine pharmacokinetics and metabolism: studies using mice deficient in CYP1A2.
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10. |
Liang HC et al. (1996) Cyp1a2(-/-) null mutant mice develop normally but show deficient drug metabolism.
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11. |
Paolini M et al. (1999) Co-carcinogenic effect of beta-carotene.
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12. |
Shimada T et al. (1994) Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.
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13. |
Devonshire HW et al. (1983) The contribution of genetically determined oxidation status to inter-individual variation in phenacetin disposition.
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14. |
None (1967) Acetophenetidin sensitivity.
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15. |
Guengerich FP et al. (1986) Human-liver cytochromes P-450 involved in polymorphisms of drug oxidation.
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16. |
Sesardic D et al. (1988) A form of cytochrome P450 in man, orthologous to form d in the rat, catalyses the O-deethylation of phenacetin and is inducible by cigarette smoking.
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17. |
Butler MA et al. (1989) Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.
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18. |
Ikeya K et al. (1989) Human CYP1A2: sequence, gene structure, comparison with the mouse and rat orthologous gene, and differences in liver 1A2 mRNA expression.
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19. |
Vistisen K et al. (1992) Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine.
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Update: Aug. 26, 2020