Increased sensitivity or resistance to vitamin K antagonists can be caused by various genetic variations in distinct genes.
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Nebert DW et al. () The P450 superfamily: update on new sequences, gene mapping, and recommended nomenclature.
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| 17. |
O'REILLY RA et al. (1964) HEREDITARY TRANSMISSION OF EXCEPTIONAL RESISTANCE TO COUMARIN ANTICOAGULANT DRUGS. THE FIRST REPORTED KINDRED.
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| 18. |
Lindberg RL et al. (1992) Molecular characterization of the murine Coh locus: an amino acid difference at position 117 confers high and low coumarin 7-hydroxylase activity in P450coh.
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Yuan HY et al. (2005) A novel functional VKORC1 promoter polymorphism is associated with inter-individual and inter-ethnic differences in warfarin sensitivity.
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et al. (2009) Estimation of the warfarin dose with clinical and pharmacogenetic data.
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Lush IE et al. (1978) Genetic variation between mice in their metabolism of coumarin and its derivatives.
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| 25. |
OMIM.ORG article Omim 122700
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