Type 28 of genetic inflammatory bowel disease is an autosomal recessive disorder caused by mutations of the IL10RB gene which codes a component of the IL10 receptor.
Inflammatory bowel disease | ||||
Crohn disease-associated growth failure | ||||
Inflammatory bowel disease 13 | ||||
Inflammatory bowel disease 25 | ||||
Inflammatory bowel disease 28 | ||||
IL10RA | ||||
SEL1L | ||||
1. |
Glocker EO et. al. (2009) Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. |
2. |
Begue B et. al. (2011) Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease. |
3. |
Mao H et. al. (2012) Exome sequencing identifies novel compound heterozygous mutations of IL-10 receptor 1 in neonatal-onset Crohn's disease. |