Type 25 of genetic inflammatory bowel disease is an autosomal recessive disorder caused by mutations of the IL10RB gene which codes a component of the IL10 receptor.
Inflammatory bowel disease | ||||
Crohn disease-associated growth failure | ||||
Inflammatory bowel disease 13 | ||||
Inflammatory bowel disease 25 | ||||
IL10RB | ||||
Inflammatory bowel disease 28 | ||||
SEL1L | ||||
1. |
Glocker EO et. al. (2009) Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. |
2. |
Begue B et. al. (2011) Defective IL10 signaling defining a subgroup of patients with inflammatory bowel disease. |
3. |
None (2007) Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. |
4. |
Silverberg MS et al. (2009) Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. |
5. |
McGovern DP et al. (2010) Genome-wide association identifies multiple ulcerative colitis susceptibility loci. |
6. |
Kugathasan S et. al. (2008) Loci on 20q13 and 21q22 are associated with pediatric-onset inflammatory bowel disease. |