Laboratory for Molecular Diagnostics
Center for Nephrology and Metabolic Disorders
Moldiag Diseases Genes Support Contact

Plasminogen

The PLG gene encodes plasminogen which is a zymogen which when activated digests fibin thrombi. Mutations cause autosomal recessive plasminogen deficiency and conjunctivitis lignosa. The cleaved off peptice has angiostatic activity. No disorder is yet known that is caused by dysfunction of that peptide.

Genetests:

Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Clinic Method Massive parallel sequencing
Turnaround 25 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Dysplasminogenemia
PLG
Hypoplasminogenemia
PLG
Hemolytic-Uremic Syndrome
ADAMTS13
C3
C4BPA
C4BPB
CD46
CFB
CFH
CFHR1
CFHR2
CFHR3
CFHR4
CFHR5
CFI
CLU
DGKE
Methylmalonic aciduria
Methylmalonic aciduria and homocystinuria cblC
MMACHC
Methylmalonic aciduria and homocystinuria cblD
MMADHC
Methylmalonic aciduria type mut
MUT
PIGA
PLG
THBD

References:

1.

Gately S et al. (1996) Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin.

external link
2.

Miyata T et al. (1984) Plasminogens Tochigi II and Nagoya: two additional molecular defects with Ala-600----Thr replacement found in plasmin light chain variants.

external link
3.

Sakata Y et al. (1980) Molecular abnormality of plasminogen.

external link
4.

Eiberg H et al. (1984) Linkage of plasma alpha-L-fucosidase (FUCA2) and the plasminogen (PLG) system.

external link
5.

Bissbort S et al. (1983) Genetic linkage relations of the human plasminogen gene.

external link
6.

Nakamura S et al. (1982) Genetic polymorphism of human plasminogen in the Japanese population: new plasminogen variants and relationship between plasminogen phenotypes and their biological activities.

external link
7.

Ikemoto S et al. (1982) Genetic polymorphism of human plasminogen in a Japanese population.

external link
8.

Kazama M et al. () Abnormal plasminogen, a case of recurrent thrombosis.

external link
9.

Raum D et al. (1980) Genetic polymorphism of human plasminogen.

external link
10.

Magnaghi P et al. (1995) A recombination event in the closely linked plasminogen and apolipoprotein(a) gene loci.

external link
11.

Ploplis VA et al. (1995) Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice.

external link
12.

Bugge TH et al. (1995) Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction.

external link
13.

Rao PH et al. (1994) Subregional mapping of 8 single copy loci to chromosome 6 by fluorescence in situ hybridization.

external link
14.

Patrassi GM et al. (1993) Unusual thrombotic-like retinopathy (Coats' disease) associated with congenital plasminogen deficiency type I.

external link
15.

Azuma H et al. (1993) Congenital plasminogen deficiency caused by a Ser572 to Pro mutation.

external link
16.

Romer J et al. (1996) Impaired wound healing in mice with a disrupted plasminogen gene.

external link
17.

Kunert A et al. (2007) Immune evasion of the human pathogen Pseudomonas aeruginosa: elongation factor Tuf is a factor H and plasminogen binding protein.

external link
18.

Cao Y et al. (1996) Kringle domains of human angiostatin. Characterization of the anti-proliferative activity on endothelial cells.

external link
19.

Boyle MD et al. (1997) Plasminogen activation by invasive human pathogens.

external link
20.

Kida M et al. (1997) Characterization of the 5'-flanking regions of plasminogen-related genes A and B.

external link
21.

Murata M et al. (1997) Ala601-Thr type dysplasminogenaemia genetically diagnosed in patients with retinochoroidal vascular disorders.

external link
22.

Cao Y et al. (1998) Expression of angiostatin cDNA in a murine fibrosarcoma suppresses primary tumor growth and produces long-term dormancy of metastases.

external link
23.

Iijima H et al. (1998) Familial dysplasminogenemia with central retinal vein and cilioretinal artery occlusion.

external link
24.

Higuchi Y et al. (1998) Plasminogen Kanagawa-I, a novel missense mutation, is caused by the amino acid substitution G732R.

external link
25.

Gebbia JA et al. (1999) The plasminogen activation system enhances brain and heart invasion in murine relapsing fever borreliosis.

external link
26.

Fischer MB et al. (2000) Binding of disease-associated prion protein to plasminogen.

external link
27.

Drixler TA et al. (2001) Angiostatin inhibits pathological but not physiological retinal angiogenesis.

external link
28.

Swaisgood CM et al. (2002) In vivo regulation of plasminogen function by plasma carboxypeptidase B.

external link
29.

Lund LR et al. (2006) Plasminogen activation independent of uPA and tPA maintains wound healing in gene-deficient mice.

external link
30.

Nguyen TM et al. (2007) Kringle 5 of human plasminogen, an angiogenesis inhibitor, induces both autophagy and apoptotic death in endothelial cells.

external link
31.

Gong Y et al. (2008) Inflammatory macrophage migration requires MMP-9 activation by plasminogen in mice.

external link
32.

Miyata T et al. (1982) Plasminogen Tochigi: inactive plasmin resulting from replacement of alanine-600 by threonine in the active site.

external link
33.

O'Reilly MS et al. (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma.

external link
34.

Soria J et al. (1983) Plasminogen Paris I: congenital abnormal plasminogen and its incidence in thrombosis.

external link
35.

McLean JW et al. () cDNA sequence of human apolipoprotein(a) is homologous to plasminogen.

external link
36.

Aoki N et al. (1978) Abnormal plasminogen. A hereditary molecular abnormality found in a patient with recurrent thrombosis.

external link
37.

Shigekiyo T et al. (1992) Type I congenital plasminogen deficiency is not a risk factor for thrombosis.

external link
38.

None (1990) Ligneous conjunctivitis: an ophthalmic disease with potentially fatal tracheobronchial obstruction. Laryngeal and tracheobronchial features.

external link
39.

Dolan G et al. (1988) Thrombovascular disease and familial plasminogen deficiency: a report of three kindreds.

external link
40.

Bateman JB et al. () Ligneous conjunctivitis: an autosomal recessive disorder.

external link
41.

Tait RC et al. (1996) Isolated familial plasminogen deficiency may not be a risk factor for thrombosis.

external link
42.

Schuster V et al. (1997) Homozygous mutations in the plasminogen gene of two unrelated girls with ligneous conjunctivitis.

external link
43.

Drew AF et al. (1998) Ligneous conjunctivitis in plasminogen-deficient mice.

external link
44.

Kao WW et al. (1998) Healing of corneal epithelial defects in plasminogen- and fibrinogen-deficient mice.

external link
45.

Schott D et al. (1998) Therapy with a purified plasminogen concentrate in an infant with ligneous conjunctivitis and homozygous plasminogen deficiency.

external link
46.

Schuster V et al. (1999) Compound-heterozygous mutations in the plasminogen gene predispose to the development of ligneous conjunctivitis.

external link
47.

Tefs K et al. (2006) Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients.

external link
48.

Wohl RC et al. (1982) Human plasminogen variant Chicago III.

external link
49.

Mannucci PM et al. (1986) Congenital plasminogen deficiency associated with venous thromboembolism: therapeutic trial with stanozolol.

external link
50.

Hach-Wunderle V et al. (1988) Congenital deficiency of plasminogen and its relationship to venous thrombosis.

external link
51.

Forsgren M et al. (1987) Molecular cloning and characterization of a full-length cDNA clone for human plasminogen.

external link
52.

Wu HL et al. (1987) Structure and formation of microplasmin.

external link
53.

Wu HL et al. (1987) Preparation and purification of microplasmin.

external link
54.

Scharrer IM et al. (1986) Investigation of a congenital abnormal plasminogen, Frankfurt I, and its relationship to thrombosis.

external link
55.

Murray JC et al. (1987) Linkage disequilibrium of plasminogen polymorphisms and assignment of the gene to human chromosome 6q26-6q27.

external link
56.

Petersen TE et al. (1990) Characterization of the gene for human plasminogen, a key proenzyme in the fibrinolytic system.

external link
57.

Degen SJ et al. (1990) Characterization of the cDNA coding for mouse plasminogen and localization of the gene to mouse chromosome 17.

external link
58.

Ichinose A et al. (1991) Two types of abnormal genes for plasminogen in families with a predisposition for thrombosis.

external link
59.

Kikuchi S et al. () Plasminogen with type-I mutation is polymorphic in the Japanese population.

external link
60.

None (1979) Genetic polymorphism of human plasminogen.

external link
61.

Schuster V et al. () Ligneous conjunctivitis.

external link
62.

NCBI article

NCBI 5340 external link
63.

OMIM.ORG article

Omim 173350 external link
64.

Orphanet article

Orphanet ID 117886 external link
65.

Wikipedia article

Wikipedia EN (Plasmin) external link
Update: Aug. 14, 2020
Copyright © 2005-2024 by Center for Nephrology and Metabolic Disorders, Dr. Mato Nagel, MD
Albert-Schweitzer-Ring 32, D-02943 Weißwasser, Germany, Tel.: +49-3576-287922, Fax: +49-3576-287944
Sitemap | Webmail | Disclaimer | Privacy Issues | Website Credits