Clusterin
The CLU gene encodes a secreted chaperone that can under some stress conditions also be found in the cell cytosol. Genetic variants have been associated with various disorder including Alzheimer, atypical hemolytic uremic syndrome, and focal segmental glomerulosclerosis.
Genetests:
Related Diseases:
References:
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McLaughlin L et al. (2000) Apolipoprotein J/clusterin limits the severity of murine autoimmune myocarditis.
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Navab M et al. (1997) Mildly oxidized LDL induces an increased apolipoprotein J/paraoxonase ratio.
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Bertrand P et al. (1995) Association of apolipoprotein E genotype with brain levels of apolipoprotein E and apolipoprotein J (clusterin) in Alzheimer disease.
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Birkenmeier EH et al. (1993) Sulfated glycoprotein-2 (Sgp-2) maps to mouse chromosome 14.
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5. |
Danik M et al. (1993) Localization of sulfated glycoprotein-2/clusterin mRNA in the rat brain by in situ hybridization.
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Fink TM et al. (1993) Human clusterin (CLI) maps to 8p21 in proximity to the lipoprotein lipase (LPL) gene.
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7. |
Wong P et al. (1994) Molecular characterization of human TRPM-2/clusterin, a gene associated with sperm maturation, apoptosis and neurodegeneration.
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8. |
Wong P et al. (1993) Genomic organization and expression of the rat TRPM-2 (clusterin) gene, a gene implicated in apoptosis.
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Dragunow M et al. (1995) Clusterin accumulates in dying neurons following status epilepticus.
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10. |
Duguid JR et al. (1989) Changes in brain gene expression shared by scrapie and Alzheimer disease.
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11. |
Kirszbaum L et al. (1989) Molecular cloning and characterization of the novel, human complement-associated protein, SP-40,40: a link between the complement and reproductive systems.
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12. |
Murphy BF et al. (1988) SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis.
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13. |
de Silva HV et al. (1990) Purification and characterization of apolipoprotein J.
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14. |
Slawin K et al. (1990) Chromosomal assignment of the human homologue encoding SGP-2.
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15. |
O'Bryan MK et al. (1990) Human seminal clusterin (SP-40,40). Isolation and characterization.
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16. |
de Silva HV et al. (1990) Apolipoprotein J: structure and tissue distribution.
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17. |
DeMattos RB et al. (2004) ApoE and clusterin cooperatively suppress Abeta levels and deposition: evidence that ApoE regulates extracellular Abeta metabolism in vivo.
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Han BH et al. (2001) Clusterin contributes to caspase-3-independent brain injury following neonatal hypoxia-ischemia.
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Ghiggeri GM et al. (2002) Depletion of clusterin in renal diseases causing nephrotic syndrome.
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Chen X et al. (2003) Clusterin as a biomarker in murine and human intestinal neoplasia.
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21. |
Dietzsch E et al. (1992) Regional localization of the gene for clusterin (SP-40,40; gene symbol CLI) to human chromosome 8p12-->p21.
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22. |
Ostermeier GC et al. (2004) Reproductive biology: delivering spermatozoan RNA to the oocyte.
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23. |
Jenne DE et al. (1992) Clusterin: the intriguing guises of a widely expressed glycoprotein.
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24. |
Zhang H et al. (2005) Clusterin inhibits apoptosis by interacting with activated Bax.
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25. |
Tobe T et al. (1991) Assignment of a human serum glycoprotein SP-40,40 gene (CLI) to chromosome 8.
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26. |
Zenkel M et al. (2006) Clusterin deficiency in eyes with pseudoexfoliation syndrome may be implicated in the aggregation and deposition of pseudoexfoliative material.
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27. |
Kamboh MI et al. (1991) Genetic studies of human apolipoproteins. XX. Genetic polymorphism of apolipoprotein J and its impact on quantitative lipid traits in normolipidemic subjects.
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28. |
Ståhl AL et al. (2009) A novel mutation in the complement regulator clusterin in recurrent hemolytic uremic syndrome.
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29. |
Purrello M et al. (1991) The gene for SP-40,40, human homolog of rat sulfated glycoprotein 2, rat clusterin, and rat testosterone-repressed prostate message 2, maps to chromosome 8.
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30. |
NCBI article
NCBI 1191
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31. |
OMIM.ORG article
Omim 185430
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32. |
Wikipedia article
Wikipedia EN (Clusterin)
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Update: Aug. 14, 2020