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C-type lectin domain family 6 member A

The CLEC6A gene encodes a C-type lectin protein, also known as dectin-2. It is an extracellular pathogen pattern receptor that bind alpha-mannan, a polysacharide predominantly found in fungal hyphae. Deficiencies cause severe fungal infections.


Clinic Method Carrier testing
Turnaround 5 days
Specimen type genomic DNA
Research Method Genomic sequencing of the entire coding region
Turnaround 25 days
Specimen type genomic DNA

Related Diseases:

Familial candidiasis
Familial candidiasis 1
Familial candidiasis 2
Familial candidiasis 3
Familial candidiasis 4
Familial candidiasis 5
Familial candidiasis 6
Familial candidiasis 8



Ritter M et al. (2010) Schistosoma mansoni triggers Dectin-2, which activates the Nlrp3 inflammasome and alters adaptive immune responses.

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Schenten D et al. (2011) The control of adaptive immune responses by the innate immune system.

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Bi L et al. (2010) CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans.

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Kanazawa N et al. (2004) Molecular cloning of human dectin-2.

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Flornes LM et al. (2004) Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex.

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Gavino AC et al. (2005) Identification and expression profiling of a human C-type lectin, structurally homologous to mouse dectin-2.

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Saijo S et al. (2010) Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans.

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Zhu LL et al. (2013) C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection.

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Yonekawa A et al. (2014) Dectin-2 is a direct receptor for mannose-capped lipoarabinomannan of mycobacteria.

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Update: Aug. 26, 2020
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